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Weak to moderate cytoplasmic immunoreactivity was observed in a few cases of breast, colorectal, ovarian, cervical and skin cancers. Remaining cancer tissues were generally negative.
A majority of cancer tissues showed weak to moderate cytoplasmic and/or nuclear positivity. Carcinoid, skin, testicular, cervical and endometrial cancers were in general negative.
GENE INFORMATION
Gene name
CAPN9 (HGNC Symbol)
Synonyms
GC36, nCL-4
Description
Calpain 9 (HGNC Symbol)
Entrez gene summary
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
