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TAF5L

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GENERAL INFORMATION

Gene name

 TAF5L

Gene description

 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles. In addition localized to the cytoplasmic bodies.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (supported)

Additional location

 In addition localized to the Cytoplasmic bodies (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA067941
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles. In addition localized to the cytoplasmic bodies.

Main location

 Nuclear speckles (supported)

Additional location

 Cytoplasmic bodies (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA067941 HEK 293 Nuclear speckles
HPA067941 U-2 OS Nuclear speckles
Cytoplasmic bodies
HPA067941 U-251 MG Nuclear speckles

GENE INFORMATION

Gene name

 TAF5L (HGNC Symbol)

Synonyms

 PAF65B

Description

 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.13

Chromosome location (bp)

 229593111 - 229626047

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135801 (version 83.38)

Entrez gene

 27097

UniProt

 O75529 (UniProt - Evidence at protein level)

neXtProt

 NX_O75529

Antibodypedia

 TAF5L antibodies

PROTEIN BROWSER
TAF5L-001
TAF5L-002
TAF5L-003
TAF5L-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAF5L-001
ENSP00000355636
ENST00000366676
O75529 [Direct mapping]
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030914 [STAGA complex]
GO:0033276 [transcription factor TFTC complex]
GO:0043966 [histone H3 acetylation]
Show all
 589 aa
66.2 kDa 		No 0
TAF5L-002
ENSP00000355635
ENST00000366675
O75529 [Direct mapping]
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030914 [STAGA complex]
GO:0033276 [transcription factor TFTC complex]
GO:0043966 [histone H3 acetylation]
Show all
 325 aa
37 kDa 		No 0
TAF5L-003
ENSP00000355634
ENST00000366674
Q5TDI7 [Direct mapping]
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 84 aa
9.2 kDa 		No 0
TAF5L-201
ENSP00000258281
ENST00000258281
O75529 [Direct mapping]
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030914 [STAGA complex]
GO:0033276 [transcription factor TFTC complex]
GO:0043966 [histone H3 acetylation]
Show all
 589 aa
66.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.