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RGS8

GENERAL INFORMATION

Gene name

 RGS8

Gene description

 Regulator of G-protein signaling 8

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (thyroid gland, cerebral cortex, testis)
GTEx:Tissue enhanced (caudate, testis)
FANTOM5:Tissue enriched (caudate)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (thyroid gland, cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (caudate)

GENE INFORMATION

Gene name

 RGS8 (HGNC Symbol)

Synonyms

 MGC119067, MGC119068, MGC119069

Description

 Regulator of G-protein signaling 8 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 182641816 - 182684576

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135824 (version 83.38)

Entrez gene

 85397

UniProt

 P57771 (UniProt - Evidence at protein level)

neXtProt

 NX_P57771

Antibodypedia

 RGS8 antibodies

PROTEIN BROWSER
RGS8-001
RGS8-003
RGS8-004
RGS8-005
RGS8-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGS8-001
ENSP00000356527
ENST00000367556
P57771 [Direct mapping]
Regulator of G-protein signaling 8
Show all
Predicted intracellular proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0009968 [negative regulation of signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 180 aa
20.9 kDa 		No 0
RGS8-003
ENSP00000258302
ENST00000258302
P57771 [Direct mapping]
Regulator of G-protein signaling 8
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0009968 [negative regulation of signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 198 aa
23 kDa 		No 0
RGS8-004
ENSP00000356528
ENST00000367557
P57771 [Direct mapping]
Regulator of G-protein signaling 8
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0009968 [negative regulation of signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 180 aa
20.9 kDa 		No 0
RGS8-005
ENSP00000426289
ENST00000483095
P57771 [Direct mapping]
Regulator of G-protein signaling 8
Show all
Predicted intracellular proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0009968 [negative regulation of signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 180 aa
20.9 kDa 		No 0
RGS8-008
ENSP00000427076
ENST00000508450
D6RD36 [Direct mapping]
Regulator of G-protein-signaling 8
Show all
Predicted intracellular proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0043547 [positive regulation of GTPase activity]
Show all
 57 aa
6.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.