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DHX9

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GENERAL INFORMATION

Gene name

 DHX9

Gene description

 DEAH (Asp-Glu-Ala-His) box helicase 9

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated)

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
CAB011819 , HPA028050 , HPA055684
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus.

Main location

 Nucleus (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB011819 A-431 Nucleoplasm
CAB011819 U-2 OS Nucleoplasm
CAB011819 U-251 MG Nucleoplasm
HPA028050 A-431 Nucleoplasm
HPA028050 U-2 OS Nucleoplasm
HPA028050 U-251 MG Nucleoplasm
HPA055684 A-431 Nucleus
Nucleoli
HPA055684 U-2 OS Nucleus
Nucleoli
HPA055684 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 DHX9 (HGNC Symbol)

Synonyms

 DDX9, LKP, RHA

Description

 DEAH (Asp-Glu-Ala-His) box helicase 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 182839369 - 182887751

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135829 (version 83.38)

Entrez gene

 1660

UniProt

 Q08211 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08211

Antibodypedia

 DHX9 antibodies

PROTEIN BROWSER
DHX9-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHX9-001
ENSP00000356520
ENST00000367549
Q08211 [Direct mapping]
ATP-dependent RNA helicase A
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000398 [mRNA splicing, via spliceosome]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001649 [osteoblast differentiation]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003724 [RNA helicase activity]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006396 [RNA processing]
GO:0007623 [circadian rhythm]
GO:0008026 [ATP-dependent helicase activity]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0032481 [positive regulation of type I interferon production]
GO:0032508 [DNA duplex unwinding]
GO:0034605 [cellular response to heat]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0070934 [CRD-mediated mRNA stabilization]
GO:0070937 [CRD-mediated mRNA stability complex]
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 1270 aa
141 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.