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RC3H1

CANCER ATLAS

Gene description

 Ring finger and CCCH-type domains 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027428
HPA027434
HPA027448

GENE INFORMATION

Gene name

 RC3H1 (HGNC Symbol)

Synonyms

 KIAA2025, RNF198, roquin, RP5-1198E17.5

Description

 Ring finger and CCCH-type domains 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 q25.1

Chromosome location (bp)

 173931214 - 174022297

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135870 (version 83.38)

Entrez gene

 149041

UniProt

 Q5TC82 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5TC82

Antibodypedia

 RC3H1 antibodies

PROTEIN BROWSER
RC3H1-001
RC3H1-003
RC3H1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RC3H1-001
ENSP00000356667
ENST00000367694
Q5TC82 [Direct mapping]
Roquin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0002634 [regulation of germinal center formation]
GO:0002635 [negative regulation of germinal center formation]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010608 [posttranscriptional regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0030889 [negative regulation of B cell proliferation]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045623 [negative regulation of T-helper cell differentiation]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0050856 [regulation of T cell receptor signaling pathway]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 1125 aa
124.8 kDa 		No 0
RC3H1-003
ENSP00000356669
ENST00000367696
Q5TC82 [Direct mapping]
Roquin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0001782 [B cell homeostasis]
GO:0002634 [regulation of germinal center formation]
GO:0002635 [negative regulation of germinal center formation]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0010468 [regulation of gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0010608 [posttranscriptional regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0030889 [negative regulation of B cell proliferation]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0042098 [T cell proliferation]
GO:0043029 [T cell homeostasis]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045623 [negative regulation of T-helper cell differentiation]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0048535 [lymph node development]
GO:0048536 [spleen development]
GO:0050856 [regulation of T cell receptor signaling pathway]
GO:0061470 [T follicular helper cell differentiation]
GO:0061630 [ubiquitin protein ligase activity]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
Show all
 1133 aa
125.7 kDa 		No 0
RC3H1-201
ENSP00000258349
ENST00000258349
Q5TC82 [Direct mapping]
Roquin-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000932 [cytoplasmic mRNA processing body]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0002634 [regulation of germinal center formation]
GO:0002635 [negative regulation of germinal center formation]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0010494 [cytoplasmic stress granule]
GO:0010608 [posttranscriptional regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0030889 [negative regulation of B cell proliferation]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045623 [negative regulation of T-helper cell differentiation]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0050856 [regulation of T cell receptor signaling pathway]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 1133 aa
125.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.