Expression of DOCK10 in cancer - Summary

CANCER ATLAS

Gene description

Dedicator of cytokinesis 10

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035749

GENE INFORMATION
Gene name	DOCK10 (HGNC Symbol)
Synonyms	KIAA0694, ZIZ3
Description	Dedicator of cytokinesis 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
Chromosome	2
Cytoband	q36.2
Chromosome location (bp)	224765090 - 225042445
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135905 (version 83.38)
Entrez gene	55619
UniProt	Q96BY6 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BY6
Antibodypedia	DOCK10 antibodies

PROTEIN BROWSER

DOCK10-001	DOCK10-002	DOCK10-006	DOCK10-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOCK10-001 ENSP00000258390 ENST00000258390	Q96BY6 [Direct mapping] Dedicator of cytokinesis protein 10 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0017048 [Rho GTPase binding] GO:0030334 [regulation of cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0070062 [extracellular exosome] Show all	2186 aa 249.5 kDa	No	0
DOCK10-002 ENSP00000386694 ENST00000409592	Q96BY6 [Direct mapping] Dedicator of cytokinesis protein 10 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0030334 [regulation of cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0070062 [extracellular exosome] Show all	2180 aa 249.5 kDa	No	0
DOCK10-006 ENSP00000395178 ENST00000422684	H7C0I3 [Direct mapping] Dedicator of cytokinesis protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	380 aa 42.6 kDa	No	0
DOCK10-014 ENSP00000437947 ENST00000535663	H0YFC5 [Direct mapping] Dedicator of cytokinesis protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	190 aa 22.1 kDa	No	0