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WNT10A

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GENERAL INFORMATION

Gene name

 WNT10A

Gene description

 Wingless-type MMTV integration site family, member 10A

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HaCaT, U-266/70, HDLM-2, CAPAN-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, U-266/70, HDLM-2, CAPAN-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 WNT10A

Synonyms

Description

 Wingless-type MMTV integration site family, member 10A (HGNC Symbol)

Entrez gene summary

 The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218880363 - 218899581

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135925 (version 83.38)

Entrez gene

 80326

UniProt

 Q9GZT5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZT5

Antibodypedia

 WNT10A antibodies

PROTEIN BROWSER
WNT10A-001
WNT10A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WNT10A-001
ENSP00000258411
ENST00000258411
Q9GZT5 [Direct mapping]
Protein Wnt-10a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0001942 [hair follicle development]
GO:0005102 [receptor binding]
GO:0005109 [frizzled binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0007275 [multicellular organismal development]
GO:0010628 [positive regulation of gene expression]
GO:0014033 [neural crest cell differentiation]
GO:0016055 [Wnt signaling pathway]
GO:0030182 [neuron differentiation]
GO:0031069 [hair follicle morphogenesis]
GO:0042476 [odontogenesis]
GO:0042487 [regulation of odontogenesis of dentin-containing tooth]
GO:0043586 [tongue development]
GO:0043588 [skin development]
GO:0045165 [cell fate commitment]
GO:0048730 [epidermis morphogenesis]
GO:0048733 [sebaceous gland development]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
Show all
 417 aa
46.4 kDa 		Yes 1
WNT10A-002
ENSP00000388812
ENST00000458582
H7BZB8 [Direct mapping]
Protein Wnt
Show all
Predicted intracellular proteins
Show all
GO:0005102 [receptor binding]
GO:0005109 [frizzled binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0007275 [multicellular organismal development]
GO:0016055 [Wnt signaling pathway]
GO:0030182 [neuron differentiation]
GO:0045165 [cell fate commitment]
Show all
 213 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.