Tissue expression of TMBIM1 - Summary - The Human Protein Atlas

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TMBIM1

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TMBIM1
Gene description	Transmembrane BAX inhibitor motif containing 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA012093
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TMBIM1 (HGNC Symbol)
Synonyms	LFG3, PP1201, RECS1
Description	Transmembrane BAX inhibitor motif containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q35
Chromosome location (bp)	218274192 - 218292586
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135926 (version 83.38)
Entrez gene	64114
UniProt	Q969X1 (UniProt - Evidence at protein level)
neXtProt	NX_Q969X1
Antibodypedia	TMBIM1 antibodies

PROTEIN BROWSER

TMBIM1-001	TMBIM1-002	TMBIM1-003	TMBIM1-007	TMBIM1-009	TMBIM1-010	TMBIM1-011	TMBIM1-012	TMBIM1-013	TMBIM1-015	TMBIM1-016	TMBIM1-017	TMBIM1-018	TMBIM1-019	TMBIM1-020	TMBIM1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMBIM1-001 ENSP00000258412 ENST00000258412	Q969X1 [Direct mapping] Protein lifeguard 3 A0A024R472 [Target identity:100%; Query identity:100%] Transmembrane BAX inhibitor motif containing 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005123 [death receptor binding] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0048553 [negative regulation of metalloenzyme activity] GO:0070062 [extracellular exosome] GO:0090005 [negative regulation of establishment of protein localization to plasma membrane] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902045 [negative regulation of Fas signaling pathway] GO:2000504 [positive regulation of blood vessel remodeling] Show all	311 aa 34.6 kDa	No	8
TMBIM1-002 ENSP00000401491 ENST00000445635	B3KSM0 [Direct mapping] Protein lifeguard 3; cDNA FLJ36592 fis, clone TRACH2014046, highly similar to Transmembrane BAX inhibitor motif-containing protein 1; cDNA FLJ54055, highly similar to Transmembrane BAX inhibitor motif-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	137 aa 15.3 kDa	No	4
TMBIM1-003 ENSP00000409738 ENST00000444881	Q969X1 [Direct mapping] Protein lifeguard 3 A0A024R472 [Target identity:100%; Query identity:100%] Transmembrane BAX inhibitor motif containing 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005123 [death receptor binding] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0048553 [negative regulation of metalloenzyme activity] GO:0070062 [extracellular exosome] GO:0090005 [negative regulation of establishment of protein localization to plasma membrane] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902045 [negative regulation of Fas signaling pathway] GO:2000504 [positive regulation of blood vessel remodeling] Show all	311 aa 34.6 kDa	No	8
TMBIM1-007 ENSP00000412518 ENST00000440422	C9IYT2 [Direct mapping] Protein lifeguard 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 11.6 kDa	No	0
TMBIM1-009 ENSP00000410136 ENST00000444183	C9JEN3 [Direct mapping] Protein lifeguard 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 11.5 kDa	No	0
TMBIM1-010 ENSP00000413624 ENST00000420341		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		8 aa 0.8 kDa	No	0
TMBIM1-011 ENSP00000395614 ENST00000453281	C9JI44 [Direct mapping] Protein lifeguard 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 8.9 kDa	No	0
TMBIM1-012 ENSP00000405516 ENST00000434015	C9JAK9 [Direct mapping] Protein lifeguard 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		67 aa 7.1 kDa	No	0
TMBIM1-013 ENSP00000408729 ENST00000413976	C9JM62 [Direct mapping] Protein lifeguard 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		46 aa 4.8 kDa	No	0
TMBIM1-015 ENSP00000399987 ENST00000429501	C9JWV9 [Direct mapping] Protein lifeguard 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	171 aa 19 kDa	No	2
TMBIM1-016 ENSP00000406744 ENST00000418569	C9IZ27 [Direct mapping] Protein lifeguard 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	151 aa 16.6 kDa	No	2
TMBIM1-017 ENSP00000403462 ENST00000444000	C9JDV0 [Direct mapping] Protein lifeguard 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 9.5 kDa	No	0
TMBIM1-018 ENSP00000410771 ENST00000453776	C9JAP5 [Direct mapping] Protein lifeguard 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 9.8 kDa	No	0
TMBIM1-019 ENSP00000394946 ENST00000451181	C9JN47 [Direct mapping] Protein lifeguard 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 7.7 kDa	No	0
TMBIM1-020 ENSP00000399345 ENST00000425694	C9JW19 [Direct mapping] Protein lifeguard 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	167 aa 18.5 kDa	No	2
TMBIM1-201 ENSP00000380025 ENST00000396809	Q969X1 [Direct mapping] Protein lifeguard 3 A0A024R472 [Target identity:100%; Query identity:100%] Transmembrane BAX inhibitor motif containing 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005123 [death receptor binding] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0048553 [negative regulation of metalloenzyme activity] GO:0070062 [extracellular exosome] GO:0090005 [negative regulation of establishment of protein localization to plasma membrane] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902045 [negative regulation of Fas signaling pathway] GO:2000504 [positive regulation of blood vessel remodeling] Show all	311 aa 34.6 kDa	No	8

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.