Cell atlas - EIF4E2 - The Human Protein Atlas

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EIF4E2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria

Human cell
	Cytosol
	Mitochondria

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GENERAL INFORMATION
Gene name	EIF4E2
Gene description	Eukaryotic translation initiation factor 4E family member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA019253
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & mitochondria.

Main location

Mitochondria (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019253	A-431	Cytosol
	HPA019253	U-2 OS	Mitochondria
	HPA019253	U-2 OS	Cytosol
	HPA019253	U-251 MG	Mitochondria
	HPA019253	U-251 MG	Cytosol

GENE INFORMATION
Gene name	EIF4E2 (HGNC Symbol)
Synonyms	4EHP, EIF4EL3, IF4e
Description	Eukaryotic translation initiation factor 4E family member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	232550052 - 232583644
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135930 (version 83.38)
Entrez gene	9470
UniProt	O60573 (UniProt - Evidence at protein level)
neXtProt	NX_O60573
Antibodypedia	EIF4E2 antibodies

PROTEIN BROWSER

EIF4E2-001	EIF4E2-002	EIF4E2-003	EIF4E2-005	EIF4E2-007	EIF4E2-008	EIF4E2-010	EIF4E2-013	EIF4E2-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF4E2-001 ENSP00000258416 ENST00000258416	O60573 [Direct mapping] Eukaryotic translation initiation factor 4E type 2 Q53RG0 [Target identity:100%; Query identity:100%] Eukaryotic translation initiation factor 4E member 2, isoform CRA_c; Putative uncharacterized protein tmp_locus_9; cDNA FLJ12456 fis, clone NT2RM1000661, highly similar to Eukaryotic translation initiation factor 4E type 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000339 [RNA cap binding] GO:0001701 [in utero embryonic development] GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0006413 [translational initiation] GO:0008135 [translation factor activity, RNA binding] GO:0017148 [negative regulation of translation] GO:0019221 [cytokine-mediated signaling pathway] GO:0031625 [ubiquitin protein ligase binding] GO:0044822 [poly(A) RNA binding] Show all	245 aa 28.4 kDa	No	0
EIF4E2-002 ENSP00000386996 ENST00000409098	O60573 [Direct mapping] Eukaryotic translation initiation factor 4E type 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000339 [RNA cap binding] GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0006413 [translational initiation] GO:0008135 [translation factor activity, RNA binding] GO:0017148 [negative regulation of translation] GO:0019221 [cytokine-mediated signaling pathway] GO:0031625 [ubiquitin protein ligase binding] GO:0044822 [poly(A) RNA binding] Show all	234 aa 27 kDa	No	0
EIF4E2-003 ENSP00000387336 ENST00000409514	B8ZZ50 [Direct mapping] Eukaryotic translation initiation factor 4E type 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0006413 [translational initiation] Show all	236 aa 27.2 kDa	No	0
EIF4E2-005 ENSP00000387328 ENST00000409167	B4E1E4 [Direct mapping] Eukaryotic translation initiation factor 4E type 2; cDNA FLJ59146, moderately similar to Eukaryotic translation initiation factor 4E type 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0006413 [translational initiation] Show all	188 aa 21.7 kDa	No	0
EIF4E2-007 ENSP00000386876 ENST00000409495	B9A044 [Direct mapping] Eukaryotic translation initiation factor 4E type 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0006413 [translational initiation] Show all	233 aa 26.8 kDa	No	0
EIF4E2-008 ENSP00000386983 ENST00000409394	B9A023 [Direct mapping] Eukaryotic translation initiation factor 4E type 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0006413 [translational initiation] Show all	189 aa 21.9 kDa	No	0
EIF4E2-010 ENSP00000390904 ENST00000454501	C9JEL3 [Direct mapping] Eukaryotic translation initiation factor 4E type 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0006413 [translational initiation] Show all	213 aa 24.6 kDa	No	0
EIF4E2-013 ENSP00000389578 ENST00000444113	H7BZH2 [Direct mapping] Eukaryotic translation initiation factor 4E type 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 12.9 kDa	No	0
EIF4E2-014 ENSP00000386424 ENST00000409322	B8ZZL3 [Direct mapping] Eukaryotic translation initiation factor 4E type 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0006413 [translational initiation] Show all	200 aa 23.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.