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REV1

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GENERAL INFORMATION

Gene name

 REV1

Gene description

 REV1, polymerase (DNA directed)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA051036
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051036 HEK 293 Cytosol
HPA051036 PC-3 No staining    
HPA051036 U-2 OS No staining    

GENE INFORMATION

Gene name

 REV1 (HGNC Symbol)

Synonyms

 REV1L

Description

 REV1, polymerase (DNA directed) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 99400475 - 99490035

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135945 (version 83.38)

Entrez gene

 51455

UniProt

 Q9UBZ9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBZ9

Antibodypedia

 REV1 antibodies

PROTEIN BROWSER
REV1-001
REV1-002
REV1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
REV1-001
ENSP00000258428
ENST00000258428
Q9UBZ9 [Direct mapping]
DNA repair protein REV1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0009411 [response to UV]
GO:0016779 [nucleotidyltransferase activity]
GO:0017125 [deoxycytidyl transferase activity]
GO:0019985 [translesion synthesis]
GO:0042276 [error-prone translesion synthesis]
Show all
 1251 aa
138.2 kDa 		No 0
REV1-002
ENSP00000377091
ENST00000393445
Q9UBZ9 [Direct mapping]
DNA repair protein REV1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0009411 [response to UV]
GO:0016779 [nucleotidyltransferase activity]
GO:0019985 [translesion synthesis]
GO:0042276 [error-prone translesion synthesis]
Show all
 1250 aa
138.2 kDa 		No 0
REV1-007
ENSP00000414875
ENST00000450415
C9JPS2 [Direct mapping]
DNA repair protein REV1
Show all
Predicted intracellular proteins
Show all
GO:0006281 [DNA repair]
Show all
 192 aa
21.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.