Tissue expression of TMEM127 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TMEM127
Gene description	Transmembrane protein 127
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TMEM127 (HGNC Symbol)
Synonyms	FLJ20507, FLJ22257
Description	Transmembrane protein 127 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2010]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	96248516 - 96265994
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135956 (version 83.38)
Entrez gene	55654
UniProt	O75204 (UniProt - Evidence at protein level)
neXtProt	NX_O75204
Antibodypedia	TMEM127 antibodies

PROTEIN BROWSER

TMEM127-001	TMEM127-002	TMEM127-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM127-001 ENSP00000258439 ENST00000258439	O75204 [Direct mapping] Transmembrane protein 127 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0007032 [endosome organization] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0017137 [Rab GTPase binding] GO:0032006 [regulation of TOR signaling] GO:0032007 [negative regulation of TOR signaling] Show all	238 aa 25.8 kDa	No	3
TMEM127-002 ENSP00000416660 ENST00000432959	O75204 [Direct mapping] Transmembrane protein 127 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0017137 [Rab GTPase binding] GO:0032007 [negative regulation of TOR signaling] Show all	238 aa 25.8 kDa	No	3
TMEM127-004 ENSP00000411810 ENST00000435268	C9J4H2 [Direct mapping] Transmembrane protein 127 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	154 aa 17.2 kDa	No	2