Cell atlas - EDAR - The Human Protein Atlas

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EDAR

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	EDAR
Gene description	Ectodysplasin A receptor
Protein class	Disease related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (HaCaT, CAPAN-2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HaCaT, CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	EDAR (HGNC Symbol)
Synonyms	DL, ED1R, ED3, ED5, EDA1R, EDA3, Edar
Description	Ectodysplasin A receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q13
Chromosome location (bp)	108894471 - 108989372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135960 (version 83.38)
Entrez gene	10913
UniProt	Q9UNE0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNE0
Antibodypedia	EDAR antibodies

PROTEIN BROWSER

EDAR-001	EDAR-002	EDAR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EDAR-001 ENSP00000258443 ENST00000258443	Q9UNE0 [Direct mapping] Tumor necrosis factor receptor superfamily member EDAR Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Show all	GO:0001942 [hair follicle development] GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0008544 [epidermis development] GO:0010628 [positive regulation of gene expression] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042346 [positive regulation of NF-kappaB import into nucleus] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0043473 [pigmentation] GO:0045177 [apical part of cell] GO:0060662 [salivary gland cavitation] Show all	448 aa 48.6 kDa	Yes	1
EDAR-002 ENSP00000386371 ENST00000409271	Q9UNE0 [Direct mapping] Tumor necrosis factor receptor superfamily member EDAR Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0008544 [epidermis development] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0033209 [tumor necrosis factor-mediated signaling pathway] Show all	480 aa 51.7 kDa	Yes	1
EDAR-201 ENSP00000365839 ENST00000376651	Q9UNE0 [Direct mapping] Tumor necrosis factor receptor superfamily member EDAR Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0008544 [epidermis development] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0033209 [tumor necrosis factor-mediated signaling pathway] Show all	480 aa 51.7 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.