Cell atlas - ALDH1L2 - The Human Protein Atlas

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ALDH1L2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	ALDH1L2
Gene description	Aldehyde dehydrogenase 1 family, member L2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Cell line enhanced (ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA039481
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039481	A-431	Mitochondria	Intensity
	HPA039481	U-2 OS	Mitochondria	Intensity
	HPA039481	U-251 MG	Mitochondria	Intensity

GENE INFORMATION
Gene name	ALDH1L2 (HGNC Symbol)
Synonyms	FLJ38508, mtFDH
Description	Aldehyde dehydrogenase 1 family, member L2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	105019784 - 105084577
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136010 (version 83.38)
Entrez gene	160428
UniProt	Q3SY69 (UniProt - Evidence at protein level)
neXtProt	NX_Q3SY69
Antibodypedia	ALDH1L2 antibodies

PROTEIN BROWSER

ALDH1L2-001	ALDH1L2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH1L2-001 ENSP00000258494 ENST00000258494	Q3SY69 [Direct mapping] Mitochondrial 10-formyltetrahydrofolate dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006730 [one-carbon metabolic process] GO:0008152 [metabolic process] GO:0008168 [methyltransferase activity] GO:0009058 [biosynthetic process] GO:0009258 [10-formyltetrahydrofolate catabolic process] GO:0016155 [formyltetrahydrofolate dehydrogenase activity] GO:0016491 [oxidoreductase activity] GO:0016742 [hydroxymethyl-, formyl- and related transferase activity] GO:0032259 [methylation] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	923 aa 101.7 kDa	No	0
ALDH1L2-005 ENSP00000447464 ENST00000548418	H0YHN9 [Direct mapping] Mitochondrial 10-formyltetrahydrofolate dehydrogenase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016155 [formyltetrahydrofolate dehydrogenase activity] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	92 aa 10.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.