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NEK3

CANCER ATLAS

Gene description

 NIMA-related kinase 3

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019062
HPA043230

GENE INFORMATION

Gene name

 NEK3 (HGNC Symbol)

Synonyms

 HSPK36, MGC29949

Description

 NIMA-related kinase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Chromosome

 13

Cytoband

 q14.3

Chromosome location (bp)

 52132639 - 52159861

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136098 (version 83.38)

Entrez gene

 4752

UniProt

 P51956 (UniProt - Evidence at protein level)

neXtProt

 NX_P51956

Antibodypedia

 NEK3 antibodies

PROTEIN BROWSER
NEK3-001
NEK3-003
NEK3-005
NEK3-008
NEK3-201
NEK3-202
NEK3-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEK3-001
ENSP00000480328
ENST00000610828
P51956 [Direct mapping]
Serine/threonine-protein kinase Nek3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0030424 [axon]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 506 aa
57.7 kDa 		No 0
NEK3-003
ENSP00000481533
ENST00000620675
A0A087WY58 [Direct mapping]
Serine/threonine-protein kinase Nek3
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 497 aa
56.7 kDa 		No 0
NEK3-005
ENSP00000449679
ENST00000550841
F8VV00 [Direct mapping]
Serine/threonine-protein kinase Nek3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 58 aa
6.7 kDa 		No 0
NEK3-008
ENSP00000483058
ENST00000618856
A0A087X030 [Direct mapping]
Serine/threonine-protein kinase Nek3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0006468 [protein phosphorylation]
Show all
 182 aa
20.4 kDa 		No 0
NEK3-201
ENSP00000484086
ENST00000611833
P51956 [Direct mapping]
Serine/threonine-protein kinase Nek3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0030424 [axon]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
Show all
 489 aa
55.9 kDa 		No 0
NEK3-202
ENSP00000484443
ENST00000618534
P51956 [Direct mapping]
Serine/threonine-protein kinase Nek3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0030010 [establishment of cell polarity]
GO:0030424 [axon]
GO:0046872 [metal ion binding]
GO:0048812 [neuron projection morphogenesis]
GO:0051301 [cell division]
GO:0090043 [regulation of tubulin deacetylation]
Show all
 506 aa
57.7 kDa 		No 0
NEK3-203
ENSP00000487230
ENST00000629912
F8VTT4 [Direct mapping]
Serine/threonine-protein kinase Nek3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 46 aa
5.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.