Tissue expression of LECT1 - Summary - The Human Protein Atlas

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LECT1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LECT1
Gene description	Leukocyte cell derived chemotaxin 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (thyroid gland, testis, salivary gland)
GTEx:	Tissue enhanced (caudate)
FANTOM5:	Tissue enhanced (salivary gland, retina, caudate)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA010510
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (thyroid gland, testis, salivary gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (salivary gland, retina, caudate)

GENE INFORMATION
Gene name	LECT1 (HGNC Symbol)
Synonyms	BRICD3, CHM-I, CHM1, chondromodulin, MYETS1
Description	Leukocyte cell derived chemotaxin 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q14.3
Chromosome location (bp)	52703264 - 52739812
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136110 (version 83.38)
Entrez gene	11061
UniProt	O75829 (UniProt - Evidence at protein level)
neXtProt	NX_O75829
Antibodypedia	LECT1 antibodies

PROTEIN BROWSER

LECT1-001	LECT1-002	LECT1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LECT1-001 ENSP00000367198 ENST00000377962	O75829 [Direct mapping] Leukocyte cell-derived chemotaxin 1 Chondrosurfactant protein Chondromodulin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001886 [endothelial cell morphogenesis] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005578 [proteinaceous extracellular matrix] GO:0006029 [proteoglycan metabolic process] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0051216 [cartilage development] Show all	334 aa 37.1 kDa	No	1
LECT1-002 ENSP00000396035 ENST00000431550	E9PKI9 [Direct mapping] Leukocyte cell-derived chemotaxin 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.1 kDa	No	0
LECT1-003 ENSP00000388576 ENST00000448904	O75829 [Direct mapping] Leukocyte cell-derived chemotaxin 1 Chondrosurfactant protein Chondromodulin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005578 [proteinaceous extracellular matrix] GO:0006029 [proteoglycan metabolic process] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] GO:0051216 [cartilage development] Show all	333 aa 37 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.