Expression of ITM2B in cancer - Summary

CANCER ATLAS

Gene description

Integral membrane protein 2B

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029292

GENE INFORMATION
Gene name	ITM2B (HGNC Symbol)
Synonyms	BRI, BRI2, BRICD2B, E25B, E3-16
Description	Integral membrane protein 2B (HGNC Symbol)
Entrez gene summary	Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Chromosome	13
Cytoband	q14.2
Chromosome location (bp)	48233158 - 48270357
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136156 (version 83.38)
Entrez gene	9445
UniProt	Q9Y287 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y287
Antibodypedia	ITM2B antibodies

PROTEIN BROWSER

ITM2B-001	ITM2B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITM2B-001 ENSP00000367828 ENST00000378565	Q9Y287 [Direct mapping] Integral membrane protein 2B BRI2, membrane form BRI2 intracellular domain BRI2C, soluble form Bri23 peptide Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0030660 [Golgi-associated vesicle membrane] GO:0031301 [integral component of organelle membrane] GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	266 aa 30.3 kDa	No	1
ITM2B-003 ENSP00000367811 ENST00000378549	Q9Y287 [Direct mapping] Integral membrane protein 2B BRI2, membrane form BRI2 intracellular domain BRI2C, soluble form Bri23 peptide Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0030660 [Golgi-associated vesicle membrane] GO:0031301 [integral component of organelle membrane] GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	160 aa 18.3 kDa	No	1