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A majority of breast and ovarian cancers showed moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
EDNRB (HGNC Symbol)
Synonyms
ETB, HSCR, HSCR2
Description
Endothelin receptor type B (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]