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NKX2-1

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GENERAL INFORMATION

Gene name

 NKX2-1

Gene description

 NK2 homeobox 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus & vesicles.

RNA cell category

 Cell line enriched (SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (uncertain), Vesicles (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA074316
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus & vesicles.

Main location

 Golgi apparatus (uncertain), Vesicles (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA074316 HEK 293 Golgi apparatus
HPA074316 U-2 OS Golgi apparatus
HPA074316 U-251 MG Vesicles

GENE INFORMATION

Gene name

 NKX2-1 (HGNC Symbol)

Synonyms

 BCH, NKX2A, TITF1, TTF-1, TTF1

Description

 NK2 homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]

Chromosome

 14

Cytoband

 q13.3

Chromosome location (bp)

 36516392 - 36521149

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136352 (version 83.38)

Entrez gene

 7080

UniProt

 P43699 (UniProt - Evidence at protein level)

neXtProt

 NX_P43699

Antibodypedia

 NKX2-1 antibodies

PROTEIN BROWSER
NKX2-1-001
NKX2-1-002
NKX2-1-003
NKX2-1-004
NKX2-1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKX2-1-001
ENSP00000429607
ENST00000498187
P43699 [Direct mapping]
Homeobox protein Nkx-2.1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001012 [RNA polymerase II regulatory region DNA binding]
GO:0001047 [core promoter binding]
GO:0001161 [intronic transcription regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007420 [brain development]
GO:0009725 [response to hormone]
GO:0010628 [positive regulation of gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0019899 [enzyme binding]
GO:0021759 [globus pallidus development]
GO:0030324 [lung development]
GO:0030336 [negative regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030878 [thyroid gland development]
GO:0030900 [forebrain development]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044213 [intronic transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048511 [rhythmic process]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
Show all
 371 aa
38.6 kDa 		No 0
NKX2-1-002
ENSP00000346879
ENST00000354822
P43699 [Direct mapping]
Homeobox protein Nkx-2.1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001012 [RNA polymerase II regulatory region DNA binding]
GO:0001047 [core promoter binding]
GO:0001161 [intronic transcription regulatory region sequence-specific DNA binding]
GO:0001764 [neuron migration]
GO:0002016 [regulation of blood volume by renin-angiotensin]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006644 [phospholipid metabolic process]
GO:0007389 [pattern specification process]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0007492 [endoderm development]
GO:0007631 [feeding behavior]
GO:0009725 [response to hormone]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0019899 [enzyme binding]
GO:0021537 [telencephalon development]
GO:0021759 [globus pallidus development]
GO:0021766 [hippocampus development]
GO:0021795 [cerebral cortex cell migration]
GO:0021798 [forebrain dorsal/ventral pattern formation]
GO:0021877 [forebrain neuron fate commitment]
GO:0021879 [forebrain neuron differentiation]
GO:0021892 [cerebral cortex GABAergic interneuron differentiation]
GO:0021895 [cerebral cortex neuron differentiation]
GO:0021983 [pituitary gland development]
GO:0022029 [telencephalon cell migration]
GO:0030324 [lung development]
GO:0030336 [negative regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030878 [thyroid gland development]
GO:0030900 [forebrain development]
GO:0031128 [developmental induction]
GO:0032496 [response to lipopolysaccharide]
GO:0033327 [Leydig cell differentiation]
GO:0042538 [hyperosmotic salinity response]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044213 [intronic transcription regulatory region DNA binding]
GO:0045471 [response to ethanol]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046545 [development of primary female sexual characteristics]
GO:0048511 [rhythmic process]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048663 [neuron fate commitment]
GO:0048709 [oligodendrocyte differentiation]
GO:0060430 [lung saccule development]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0060486 [Clara cell differentiation]
GO:0060510 [Type II pneumocyte differentiation]
Show all
 401 aa
41.7 kDa 		No 0
NKX2-1-003
ENSP00000429519
ENST00000522719
P43699 [Direct mapping]
Homeobox protein Nkx-2.1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001012 [RNA polymerase II regulatory region DNA binding]
GO:0001047 [core promoter binding]
GO:0001161 [intronic transcription regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007420 [brain development]
GO:0009725 [response to hormone]
GO:0010628 [positive regulation of gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0019899 [enzyme binding]
GO:0021759 [globus pallidus development]
GO:0030324 [lung development]
GO:0030336 [negative regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030878 [thyroid gland development]
GO:0030900 [forebrain development]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044213 [intronic transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048511 [rhythmic process]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
Show all
 371 aa
38.6 kDa 		No 0
NKX2-1-004
ENSP00000428341
ENST00000518149
P43699 [Direct mapping]
Homeobox protein Nkx-2.1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001012 [RNA polymerase II regulatory region DNA binding]
GO:0001047 [core promoter binding]
GO:0001161 [intronic transcription regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007420 [brain development]
GO:0009725 [response to hormone]
GO:0010628 [positive regulation of gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0019899 [enzyme binding]
GO:0021759 [globus pallidus development]
GO:0030324 [lung development]
GO:0030336 [negative regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030878 [thyroid gland development]
GO:0030900 [forebrain development]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044213 [intronic transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048511 [rhythmic process]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
Show all
 371 aa
38.6 kDa 		No 0
NKX2-1-005
ENSP00000449302
ENST00000546983
F8VVG2 [Direct mapping]
Homeobox protein Nkx-2.1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
 34 aa
3.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.