Expression of IREB2 in cancer - Summary

CANCER ATLAS

Gene description

Iron-responsive element binding protein 2

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA068982	CAB032885

GENE INFORMATION
Gene name	IREB2 (HGNC Symbol)
Synonyms	IRP2
Description	Iron-responsive element binding protein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	78437431 - 78501456
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136381 (version 83.38)
Entrez gene	3658
UniProt	P48200 (UniProt - Evidence at protein level)
neXtProt	NX_P48200
Antibodypedia	IREB2 antibodies

PROTEIN BROWSER

IREB2-001	IREB2-002	IREB2-004	IREB2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IREB2-001 ENSP00000258886 ENST00000258886	A0A0A6YY96 [Direct mapping] Iron-responsive element-binding protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006417 [regulation of translation] GO:0006782 [protoporphyrinogen IX biosynthetic process] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0007568 [aging] GO:0008152 [metabolic process] GO:0009791 [post-embryonic development] GO:0010040 [response to iron(II) ion] GO:0010468 [regulation of gene expression] GO:0017148 [negative regulation of translation] GO:0030316 [osteoclast differentiation] GO:0030350 [iron-responsive element binding] GO:0030371 [translation repressor activity] GO:0032526 [response to retinoic acid] GO:0034101 [erythrocyte homeostasis] GO:0050892 [intestinal absorption] GO:0055072 [iron ion homeostasis] GO:0071456 [cellular response to hypoxia] Show all	963 aa 105.1 kDa	No	0
IREB2-002 ENSP00000452938 ENST00000560440	P48200 [Direct mapping] Iron-responsive element-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008152 [metabolic process] GO:0017148 [negative regulation of translation] GO:0030350 [iron-responsive element binding] GO:0030371 [translation repressor activity] GO:0046872 [metal ion binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	343 aa 37.5 kDa	No	0
IREB2-004 ENSP00000453172 ENST00000560840	H0YLE0 [Direct mapping] Iron-responsive element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008152 [metabolic process] GO:0017148 [negative regulation of translation] GO:0030350 [iron-responsive element binding] GO:0030371 [translation repressor activity] Show all	38 aa 4.4 kDa	No	0
IREB2-009 ENSP00000453863 ENST00000559091	H0YN46 [Direct mapping] Iron-responsive element-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006826 [iron ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0008152 [metabolic process] GO:0017148 [negative regulation of translation] GO:0030350 [iron-responsive element binding] GO:0030371 [translation repressor activity] Show all	89 aa 9.5 kDa	No	0