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ACTL6A

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GENERAL INFORMATION

Gene name

 ACTL6A

Gene description

 Actin-like 6A

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Additional location

 In addition localized to the Cytosol (uncertain)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB012188 , HPA018671
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (validated)

Additional location

 Cytosol (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB012188 A-431 Nucleoplasm
Cytosol
CAB012188 U-2 OS Nucleoplasm
Cytosol
CAB012188 U-251 MG Nucleoplasm
Cytosol
HPA018671 A-431 Nucleoplasm
HPA018671 U-2 OS Nucleoplasm
HPA018671 U-251 MG No staining    

GENE INFORMATION

Gene name

 ACTL6A (HGNC Symbol)

Synonyms

 Actl6, Arp4, BAF53A, INO80K

Description

 Actin-like 6A (HGNC Symbol)

Entrez gene summary

 This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q26.33

Chromosome location (bp)

 179562880 - 179588408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136518 (version 83.38)

Entrez gene

 86

UniProt

 O96019 (UniProt - Evidence at protein level)

neXtProt

 NX_O96019

Antibodypedia

 ACTL6A antibodies

PROTEIN BROWSER
ACTL6A-001
ACTL6A-002
ACTL6A-009
ACTL6A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACTL6A-001
ENSP00000397552
ENST00000429709
O96019 [Direct mapping]
Actin-like protein 6A
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003407 [neural retina development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0016514 [SWI/SNF complex]
GO:0021510 [spinal cord development]
GO:0031011 [Ino80 complex]
GO:0031492 [nucleosomal DNA binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0071564 [npBAF complex]
GO:0090544 [BAF-type complex]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 429 aa
47.5 kDa 		No 0
ACTL6A-002
ENSP00000394014
ENST00000450518
O96019 [Direct mapping]
Actin-like protein 6A
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003407 [neural retina development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0016514 [SWI/SNF complex]
GO:0031011 [Ino80 complex]
GO:0031492 [nucleosomal DNA binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0071564 [npBAF complex]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 387 aa
43.2 kDa 		No 0
ACTL6A-009
ENSP00000420153
ENST00000490364
C9JQT2 [Direct mapping]
Actin-like protein 6A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0071564 [npBAF complex]
Show all
 50 aa
5.5 kDa 		No 0
ACTL6A-201
ENSP00000376430
ENST00000392662
O96019 [Direct mapping]
Actin-like protein 6A
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003407 [neural retina development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0016514 [SWI/SNF complex]
GO:0031011 [Ino80 complex]
GO:0031492 [nucleosomal DNA binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0071564 [npBAF complex]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 387 aa
43.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.