Tissue expression of TBR1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TBR1
Gene description	T-box, brain, 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Tissue enriched (cerebral cortex)
FANTOM5:	Group enriched (brain, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, hippocampus)

GENE INFORMATION
Gene name	TBR1
Synonyms
Description	T-box, brain, 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q24.2
Chromosome location (bp)	161416094 - 161425870
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136535 (version 83.38)
Entrez gene	10716
UniProt	Q16650 (UniProt - Evidence at transcript level)
neXtProt	NX_Q16650
Antibodypedia	TBR1 antibodies

PROTEIN BROWSER

TBR1-001	TBR1-002	TBR1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBR1-001 ENSP00000374205 ENST00000389554	Q16650 [Direct mapping] T-box brain protein 1 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Show all	GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001661 [conditioned taste aversion] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007420 [brain development] GO:0010092 [specification of organ identity] GO:0010468 [regulation of gene expression] GO:0010975 [regulation of neuron projection development] GO:0021764 [amygdala development] GO:0021902 [commitment of neuronal cell to specific neuron type in forebrain] GO:0030182 [neuron differentiation] GO:0030902 [hindbrain development] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1902667 [regulation of axon guidance] Show all	682 aa 74.1 kDa	No	0
TBR1-002 ENSP00000387023 ENST00000410035	Q16650 [Direct mapping] T-box brain protein 1 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007420 [brain development] Show all	395 aa 42.3 kDa	No	0
TBR1-006 ENSP00000393934 ENST00000411412	H7C0B1 [Direct mapping] T-box brain protein 1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	233 aa 25.5 kDa	No	0