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BLK

GENERAL INFORMATION

Gene name

 BLK

Gene description

 BLK proto-oncogene, Src family tyrosine kinase

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (lymph node, tonsil, spleen, appendix)
GTEx:Group enriched (spleen, small intestine)
FANTOM5:Group enriched (tonsil, appendix, spleen, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in lymphatic tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB005093
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lymph node, tonsil, spleen, appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, appendix, spleen, lymph node)

GENE INFORMATION

Gene name

 BLK (HGNC Symbol)

Synonyms

 MGC10442

Description

 BLK proto-oncogene, Src family tyrosine kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

Chromosome

 8

Cytoband

 p23.1

Chromosome location (bp)

 11494001 - 11564604

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136573 (version 83.38)

Entrez gene

 640

UniProt

 P51451 (UniProt - Evidence at protein level)

neXtProt

 NX_P51451

Antibodypedia

 BLK antibodies

PROTEIN BROWSER
BLK-001
BLK-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BLK-001
ENSP00000259089
ENST00000259089
P51451 [Direct mapping]
Tyrosine-protein kinase Blk
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030217 [T cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032024 [positive regulation of insulin secretion]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
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 505 aa
57.7 kDa 		No 0
BLK-004
ENSP00000433663
ENST00000529894
E9PJX5 [Direct mapping]
Non-specific protein-tyrosine kinase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030217 [T cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0071375 [cellular response to peptide hormone stimulus]
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 434 aa
49.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.