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Most malignant cells displayed moderate to strong nuclear immunoreactivity.
GENE INFORMATION
Gene name
GATA4
Synonyms
Description
GATA binding protein 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001947 [heart looping] GO:0003197 [endocardial cushion development] GO:0003208 [cardiac ventricle morphogenesis] GO:0003215 [cardiac right ventricle morphogenesis] GO:0003281 [ventricular septum development] GO:0003289 [atrial septum primum morphogenesis] GO:0003290 [atrial septum secundum morphogenesis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007267 [cell-cell signaling] GO:0007492 [endoderm development] GO:0007596 [blood coagulation] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008584 [male gonad development] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0033613 [activating transcription factor binding] GO:0035054 [embryonic heart tube anterior/posterior pattern specification] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045165 [cell fate commitment] GO:0045766 [positive regulation of angiogenesis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048468 [cell development] GO:0048617 [embryonic foregut morphogenesis] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0051891 [positive regulation of cardioblast differentiation] GO:0060413 [atrial septum morphogenesis] GO:0060575 [intestinal epithelial cell differentiation] GO:0070410 [co-SMAD binding] GO:0090575 [RNA polymerase II transcription factor complex]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001158 [enhancer sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001701 [in utero embryonic development] GO:0001702 [gastrulation with mouth forming second] GO:0001706 [endoderm formation] GO:0001947 [heart looping] GO:0003181 [atrioventricular valve morphogenesis] GO:0003197 [endocardial cushion development] GO:0003208 [cardiac ventricle morphogenesis] GO:0003215 [cardiac right ventricle morphogenesis] GO:0003229 [ventricular cardiac muscle tissue development] GO:0003281 [ventricular septum development] GO:0003289 [atrial septum primum morphogenesis] GO:0003290 [atrial septum secundum morphogenesis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007267 [cell-cell signaling] GO:0007283 [spermatogenesis] GO:0007492 [endoderm development] GO:0007507 [heart development] GO:0007596 [blood coagulation] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008584 [male gonad development] GO:0009612 [response to mechanical stimulus] GO:0010468 [regulation of gene expression] GO:0010507 [negative regulation of autophagy] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0014898 [cardiac muscle hypertrophy in response to stress] GO:0019901 [protein kinase binding] GO:0023019 [signal transduction involved in regulation of gene expression] GO:0030509 [BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0033189 [response to vitamin A] GO:0033613 [activating transcription factor binding] GO:0035050 [embryonic heart tube development] GO:0035054 [embryonic heart tube anterior/posterior pattern specification] GO:0035239 [tube morphogenesis] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0044212 [transcription regulatory region DNA binding] GO:0045165 [cell fate commitment] GO:0045766 [positive regulation of angiogenesis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048468 [cell development] GO:0048557 [embryonic digestive tract morphogenesis] GO:0048598 [embryonic morphogenesis] GO:0048617 [embryonic foregut morphogenesis] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0048738 [cardiac muscle tissue development] GO:0051525 [NFAT protein binding] GO:0051891 [positive regulation of cardioblast differentiation] GO:0055007 [cardiac muscle cell differentiation] GO:0060008 [Sertoli cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060070 [canonical Wnt signaling pathway] GO:0060290 [transdifferentiation] GO:0060395 [SMAD protein signal transduction] GO:0060413 [atrial septum morphogenesis] GO:0060464 [lung lobe formation] GO:0060575 [intestinal epithelial cell differentiation] GO:0061049 [cell growth involved in cardiac muscle cell development] GO:0070410 [co-SMAD binding] GO:0071333 [cellular response to glucose stimulus] GO:0071371 [cellular response to gonadotropin stimulus] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0072148 [epithelial cell fate commitment] GO:0072520 [seminiferous tubule development] GO:0086004 [regulation of cardiac muscle cell contraction] GO:0090575 [RNA polymerase II transcription factor complex]