Cell atlas - VPS45 - The Human Protein Atlas

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VPS45

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	VPS45
Gene description	Vacuolar protein sorting 45 homolog (S. cerevisiae)
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA027425
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules.

Main location

Microtubules (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA027425	A-431	Microtubules
	HPA027425	U-2 OS	Microtubules
	HPA027425	U-251 MG	Microtubules

GENE INFORMATION
Gene name	VPS45 (HGNC Symbol)
Synonyms	h-vps45, H1, VPS45A, VPS45B
Description	Vacuolar protein sorting 45 homolog (S. cerevisiae) (HGNC Symbol)
Entrez gene summary	Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	150067293 - 150145327
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136631 (version 83.38)
Entrez gene	11311
UniProt	Q9NRW7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRW7
Antibodypedia	VPS45 antibodies

PROTEIN BROWSER

VPS45-001	VPS45-010	VPS45-011	VPS45-201	VPS45-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VPS45-001 ENSP00000358126 ENST00000369130	Q9NRW7 [Direct mapping] Vacuolar protein sorting-associated protein 45 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005794 [Golgi apparatus] GO:0006886 [intracellular protein transport] GO:0006904 [vesicle docking involved in exocytosis] GO:0007596 [blood coagulation] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] Show all	570 aa 65.1 kDa	No	0
VPS45-010 ENSP00000400143 ENST00000419023	Q5T4Q0 [Direct mapping] Vacuolar protein sorting 45 homolog (S. cerevisiae); Vacuolar protein sorting-associated protein 45 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006904 [vesicle docking involved in exocytosis] GO:0016192 [vesicle-mediated transport] Show all	316 aa 36.6 kDa	No	0
VPS45-011 ENSP00000358124 ENST00000369128	Q9NRW7 [Direct mapping] Vacuolar protein sorting-associated protein 45 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005794 [Golgi apparatus] GO:0006886 [intracellular protein transport] GO:0006904 [vesicle docking involved in exocytosis] GO:0007596 [blood coagulation] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] Show all	538 aa 62 kDa	No	0
VPS45-201 ENSP00000440690 ENST00000535106	Q9NRW7 [Direct mapping] Vacuolar protein sorting-associated protein 45 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005794 [Golgi apparatus] GO:0006886 [intracellular protein transport] GO:0006904 [vesicle docking involved in exocytosis] GO:0007596 [blood coagulation] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] Show all	538 aa 62 kDa	No	0
VPS45-202 ENSP00000478403 ENST00000611412	A0A087WU65 [Direct mapping] Vacuolar protein sorting-associated protein 45 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006904 [vesicle docking involved in exocytosis] GO:0016192 [vesicle-mediated transport] Show all	447 aa 50.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.