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Most cancer cells were negative. Strong cytoplasmic positivity, with additional membranous positivity was observed in gliomas and ovarian cancers as well as several endometrial cancers and a few breast, cervical and urothelial cancers.
GENE INFORMATION
Gene name
IL10 (HGNC Symbol)
Synonyms
CSIF, IL-10, IL10A, TGIF
Description
Interleukin 10 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]