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IL1RN

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GENERAL INFORMATION

Gene name

 IL1RN

Gene description

 Interleukin 1 receptor antagonist

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HaCaT, RT4, A-431)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, RT4, A-431)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 IL1RN (HGNC Symbol)

Synonyms

 ICIL-1RA, IL-1RN, IL1F3, IL1RA, IRAP, MGC10430

Description

 Interleukin 1 receptor antagonist (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q14.1

Chromosome location (bp)

 113107214 - 113134016

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136689 (version 83.38)

Entrez gene

 3557

UniProt

 P18510 (UniProt - Evidence at protein level)

neXtProt

 NX_P18510

Antibodypedia

 IL1RN antibodies

PROTEIN BROWSER
IL1RN-001
IL1RN-002
IL1RN-003
IL1RN-004
IL1RN-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL1RN-001
ENSP00000259206
ENST00000259206
P18510 [Direct mapping]
Interleukin-1 receptor antagonist protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660 [fever generation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005152 [interleukin-1 receptor antagonist activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006953 [acute-phase response]
GO:0006955 [immune response]
GO:0030073 [insulin secretion]
GO:0031982 [vesicle]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0045352 [interleukin-1 Type I receptor antagonist activity]
GO:0045353 [interleukin-1 Type II receptor antagonist activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000660 [negative regulation of interleukin-1-mediated signaling pathway]
Show all
 180 aa
19.9 kDa 		No 0
IL1RN-002
ENSP00000329072
ENST00000354115
P18510 [Direct mapping]
Interleukin-1 receptor antagonist protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660 [fever generation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005152 [interleukin-1 receptor antagonist activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0006955 [immune response]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0045352 [interleukin-1 Type I receptor antagonist activity]
GO:0045353 [interleukin-1 Type II receptor antagonist activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000660 [negative regulation of interleukin-1-mediated signaling pathway]
Show all
 159 aa
17.9 kDa 		No 0
IL1RN-003
ENSP00000354816
ENST00000361779
P18510 [Direct mapping]
Interleukin-1 receptor antagonist protein
A0A024R528 [Target identity:100%; Query identity:100%]
Interleukin 1 receptor antagonist, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660 [fever generation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005152 [interleukin-1 receptor antagonist activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0006955 [immune response]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0045352 [interleukin-1 Type I receptor antagonist activity]
GO:0045353 [interleukin-1 Type II receptor antagonist activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000660 [negative regulation of interleukin-1-mediated signaling pathway]
Show all
 143 aa
16.1 kDa 		No 0
IL1RN-004
ENSP00000387210
ENST00000409052
P18510 [Direct mapping]
Interleukin-1 receptor antagonist protein
A0A024R528 [Target identity:100%; Query identity:100%]
Interleukin 1 receptor antagonist, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660 [fever generation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005152 [interleukin-1 receptor antagonist activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0006955 [immune response]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0045352 [interleukin-1 Type I receptor antagonist activity]
GO:0045353 [interleukin-1 Type II receptor antagonist activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000660 [negative regulation of interleukin-1-mediated signaling pathway]
Show all
 143 aa
16.1 kDa 		No 0
IL1RN-005
ENSP00000387173
ENST00000409930
P18510 [Direct mapping]
Interleukin-1 receptor antagonist protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660 [fever generation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005152 [interleukin-1 receptor antagonist activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0006955 [immune response]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0045352 [interleukin-1 Type I receptor antagonist activity]
GO:0045353 [interleukin-1 Type II receptor antagonist activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000660 [negative regulation of interleukin-1-mediated signaling pathway]
Show all
 177 aa
20.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.