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Rare cases of prostate cancer and carcinoid displayed strong cytoplasmic positivity. Several gliomas, cervical cancers along with few skin, testis, renal and pancreas cancers showed weak to moderate cytoplasmic positivity. Other cancer tissues were in general negative.
GENE INFORMATION
Gene name
CFC1 (HGNC Symbol)
Synonyms
CRYPTIC, HTX2
Description
Cripto, FRL-1, cryptic family 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
