Cell atlas - SMPD4 - The Human Protein Atlas

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SMPD4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear membrane

Human cell
	Cytosol
	Nuclear membrane

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GENERAL INFORMATION
Gene name	SMPD4
Gene description	Sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049426
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane. In addition localized to the cytosol.

Main location

Nuclear membrane (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049426	HEK 293	Nuclear membrane
	HPA049426	HEK 293	Cytosol
	HPA049426	MCF7	Nuclear membrane
	HPA049426	U-2 OS	Nuclear membrane

GENE INFORMATION
Gene name	SMPD4 (HGNC Symbol)
Synonyms	FLJ20297, FLJ20756, KIAA1418, NET13, nSMase-3, NSMASE3
Description	Sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) (HGNC Symbol)
Entrez gene summary	Sphingomyelinases (EC 3.1.4.12), such as SMPD4, catalyze the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (Krut et al., 2006 [PubMed 16517606]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	q21.1
Chromosome location (bp)	130151392 - 130182750
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136699 (version 83.38)
Entrez gene	55627
UniProt	Q9NXE4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NXE4
Antibodypedia	SMPD4 antibodies

PROTEIN BROWSER

SMPD4-001	SMPD4-002	SMPD4-004	SMPD4-009	SMPD4-014	SMPD4-015	SMPD4-016	SMPD4-020	SMPD4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMPD4-001 ENSP00000386531 ENST00000409031	B1PBA3 [Direct mapping] SKNY protein; Sphingomyelin phosphodiesterase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0050290 [sphingomyelin phosphodiesterase D activity] Show all	866 aa 97.8 kDa	No	1
SMPD4-002 ENSP00000259217 ENST00000351288	H7BXF4 [Direct mapping] Sphingomyelin phosphodiesterase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0050290 [sphingomyelin phosphodiesterase D activity] Show all	837 aa 94.6 kDa	No	1
SMPD4-004 ENSP00000401648 ENST00000439886	H7C1Q6 [Direct mapping] Sphingomyelin phosphodiesterase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0050290 [sphingomyelin phosphodiesterase D activity] Show all	741 aa 83.1 kDa	No	1
SMPD4-009 ENSP00000403915 ENST00000449159	H7C235 [Direct mapping] Sphingomyelin phosphodiesterase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0050290 [sphingomyelin phosphodiesterase D activity] Show all	211 aa 23.8 kDa	No	0
SMPD4-014 ENSP00000397078 ENST00000457039	H7C0W5 [Direct mapping] Sphingomyelin phosphodiesterase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0050290 [sphingomyelin phosphodiesterase D activity] Show all	313 aa 35.6 kDa	No	0
SMPD4-015 ENSP00000406325 ENST00000430682	H7C2J2 [Direct mapping] Sphingomyelin phosphodiesterase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0050290 [sphingomyelin phosphodiesterase D activity] Show all	274 aa 31.1 kDa	No	0
SMPD4-016 ENSP00000405363 ENST00000451542	H7C2E2 [Direct mapping] Sphingomyelin phosphodiesterase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0050290 [sphingomyelin phosphodiesterase D activity] Show all	265 aa 30.3 kDa	No	0
SMPD4-020 ENSP00000406458 ENST00000441135	C9J647 [Direct mapping] Sphingomyelin phosphodiesterase 4 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0050290 [sphingomyelin phosphodiesterase D activity] Show all	135 aa 15.3 kDa	No	0
SMPD4-201 ENSP00000405187 ENST00000431183	Q9NXE4 [Direct mapping] Sphingomyelin phosphodiesterase 4 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004767 [sphingomyelin phosphodiesterase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0006665 [sphingolipid metabolic process] GO:0006685 [sphingomyelin catabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0046475 [glycerophospholipid catabolic process] GO:0046513 [ceramide biosynthetic process] GO:0046872 [metal ion binding] GO:0050290 [sphingomyelin phosphodiesterase D activity] GO:0071356 [cellular response to tumor necrosis factor] Show all	764 aa 86.2 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.