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Colorectal and breast cancers showed moderate to strong nuclear staining often combined with cytoplasmic positivity. Several cases of malignant gliomas, lymphomas, testicular and urothelial cancers were moderately stained. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
WDR33 (HGNC Symbol)
Synonyms
FLJ11294, NET14, WDC146
Description
WD repeat domain 33 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
