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HS6ST1

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GENERAL INFORMATION

Gene name

 HS6ST1

Gene description

 Heparan sulfate 6-O-sulfotransferase 1

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA044586
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA044586 A-431 Nucleoplasm
HPA044586 U-2 OS Nucleoplasm
HPA044586 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 HS6ST1 (HGNC Symbol)

Synonyms

 HS6ST

Description

 Heparan sulfate 6-O-sulfotransferase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q14.3

Chromosome location (bp)

 128236716 - 128318577

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136720 (version 83.38)

Entrez gene

 9394

UniProt

 O60243 (UniProt - Evidence at protein level)

neXtProt

 NX_O60243

Antibodypedia

 HS6ST1 antibodies

PROTEIN BROWSER
HS6ST1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HS6ST1-001
ENSP00000259241
ENST00000259241
O60243 [Direct mapping]
Heparan-sulfate 6-O-sulfotransferase 1
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0000139 [Golgi membrane]
GO:0001525 [angiogenesis]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0008146 [sulfotransferase activity]
GO:0015012 [heparan sulfate proteoglycan biosynthetic process]
GO:0015015 [heparan sulfate proteoglycan biosynthetic process, enzymatic modification]
GO:0016021 [integral component of membrane]
GO:0017095 [heparan sulfate 6-O-sulfotransferase activity]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048286 [lung alveolus development]
GO:0048666 [neuron development]
GO:0060716 [labyrinthine layer blood vessel development]
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 411 aa
48.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.