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Strong nuclear staining was observed in most cancers. Hepatocellular carcinomas displayed weaker positivity than cholangiocarcinomas that were generally strongly stained.
Cancer cells showed strong nuclear immunoreactivity.
GENE INFORMATION
Gene name
CDK9 (HGNC Symbol)
Synonyms
C-2k, CDC2L4, PITALRE, TAK
Description
Cyclin-dependent kinase 9 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006282 [regulation of DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008023 [transcription elongation factor complex] GO:0008024 [positive transcription elongation factor complex b] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0010467 [gene expression] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016605 [PML body] GO:0017069 [snRNA binding] GO:0031056 [regulation of histone modification] GO:0031297 [replication fork processing] GO:0033129 [positive regulation of histone phosphorylation] GO:0042493 [response to drug] GO:0043231 [intracellular membrane-bounded organelle] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050434 [positive regulation of viral transcription] GO:0071157 [negative regulation of cell cycle arrest] GO:0071345 [cellular response to cytokine stimulus] GO:1900364 [negative regulation of mRNA polyadenylation] GO:1903839 [positive regulation of mRNA 3'-UTR binding] GO:2001168 [positive regulation of histone H2B ubiquitination]
