Expression of SLC2A8 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 2 (facilitated glucose transporter), member 8

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA011935

GENE INFORMATION
Gene name	SLC2A8 (HGNC Symbol)
Synonyms	GLUT8, GLUTX1
Description	Solute carrier family 2 (facilitated glucose transporter), member 8 (HGNC Symbol)
Entrez gene summary	This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Chromosome	9
Cytoband	q33.3
Chromosome location (bp)	127397138 - 127408424
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136856 (version 83.38)
Entrez gene	29988
UniProt	Q9NY64 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NY64
Antibodypedia	SLC2A8 antibodies

PROTEIN BROWSER

SLC2A8-005	SLC2A8-006	SLC2A8-008	SLC2A8-010	SLC2A8-011	SLC2A8-012	SLC2A8-013	SLC2A8-014	SLC2A8-015	SLC2A8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC2A8-005 ENSP00000362469 ENST00000373371	Q9NY64 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 8 A0A024R871 [Target identity:100%; Query identity:100%] Solute carrier family 2, (Facilitated glucose transporter) member 8, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005536 [glucose binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0007141 [male meiosis I] GO:0008021 [synaptic vesicle] GO:0008286 [insulin receptor signaling pathway] GO:0015758 [glucose transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	477 aa 50.8 kDa	No	>9
SLC2A8-006 ENSP00000362458 ENST00000373360	Q5VVV9 [Direct mapping] Solute carrier family 2, (Facilitated glucose transporter) member 8, isoform CRA_b; Solute carrier family 2, facilitated glucose transporter member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	411 aa 43.5 kDa	No	>9
SLC2A8-008 ENSP00000392434 ENST00000451404	Q5VVV3 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	265 aa 28.8 kDa	No	6
SLC2A8-010 ENSP00000411726 ENST00000419917	Q5VVW0 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	256 aa 27.8 kDa	No	5
SLC2A8-011 ENSP00000362450 ENST00000373352	Q5VVW5 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	214 aa 23 kDa	No	5
SLC2A8-012 ENSP00000413973 ENST00000419132	H0Y7M6 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005351 [sugar:proton symporter activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	169 aa 18.4 kDa	No	2
SLC2A8-013 ENSP00000404893 ENST00000439597	Q5VVV6 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	241 aa 26 kDa	No	5
SLC2A8-014 ENSP00000389070 ENST00000423934	Q5VVV5 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	267 aa 28.9 kDa	No	6
SLC2A8-015 ENSP00000391213 ENST00000430147	Q5VVV4 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	276 aa 30.1 kDa	No	6
SLC2A8-201 ENSP00000477568 ENST00000610552	A0A087WT42 [Direct mapping] Solute carrier family 2, (Facilitated glucose transporter) member 8, isoform CRA_c; Solute carrier family 2, facilitated glucose transporter member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	314 aa 34.4 kDa	No	7