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CDK5RAP2

CANCER ATLAS

Gene description

 CDK5 regulatory subunit associated protein 2

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046529

GENE INFORMATION

Gene name

 CDK5RAP2 (HGNC Symbol)

Synonyms

 C48, CEP215, FLJ10867, MCPH3

Description

 CDK5 regulatory subunit associated protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Chromosome

 9

Cytoband

 q33.2

Chromosome location (bp)

 120388869 - 120580170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136861 (version 83.38)

Entrez gene

 55755

UniProt

 Q96SN8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96SN8

Antibodypedia

 CDK5RAP2 antibodies

PROTEIN BROWSER
CDK5RAP2-005
CDK5RAP2-008
CDK5RAP2-013
CDK5RAP2-014
CDK5RAP2-017
CDK5RAP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDK5RAP2-005
ENSP00000343818
ENST00000349780
Q96SN8 [Direct mapping]
CDK5 regulatory subunit-associated protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000242 [pericentriolar material]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007059 [chromosome segregation]
GO:0007420 [brain development]
GO:0008017 [microtubule binding]
GO:0015631 [tubulin binding]
GO:0019901 [protein kinase binding]
GO:0022008 [neurogenesis]
GO:0030054 [cell junction]
GO:0032403 [protein complex binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045664 [regulation of neuron differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046600 [negative regulation of centriole replication]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051297 [centrosome organization]
GO:0070062 [extracellular exosome]
GO:0090231 [regulation of spindle checkpoint]
Show all
 1893 aa
215 kDa 		No 0
CDK5RAP2-008
ENSP00000400395
ENST00000416449
B1AMJ5 [Direct mapping]
CDK5 regulatory subunit-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0030054 [cell junction]
Show all
 1287 aa
145.6 kDa 		No 0
CDK5RAP2-013
ENSP00000409941
ENST00000425647
Q5JTU8 [Direct mapping]
CDK5 regulatory subunit-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0030054 [cell junction]
Show all
 903 aa
102.3 kDa 		No 0
CDK5RAP2-014
ENSP00000353317
ENST00000360190
Q96SN8 [Direct mapping]
CDK5 regulatory subunit-associated protein 2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000242 [pericentriolar material]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0001578 [microtubule bundle formation]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007059 [chromosome segregation]
GO:0007420 [brain development]
GO:0008017 [microtubule binding]
GO:0015631 [tubulin binding]
GO:0019901 [protein kinase binding]
GO:0022008 [neurogenesis]
GO:0030054 [cell junction]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045664 [regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046600 [negative regulation of centriole replication]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051297 [centrosome organization]
GO:0070062 [extracellular exosome]
GO:0090231 [regulation of spindle checkpoint]
Show all
 1814 aa
206.3 kDa 		No 0
CDK5RAP2-017
ENSP00000419640
ENST00000482047
C9K0C9 [Direct mapping]
CDK5 regulatory subunit-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 133 aa
15.1 kDa 		No 0
CDK5RAP2-201
ENSP00000354065
ENST00000360822
A0A0A0MRG9 [Direct mapping]
CDK5 regulatory subunit-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005815 [microtubule organizing center]
Show all
 1663 aa
189.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.