Tissue expression of FPGS - Summary - The Human Protein Atlas

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FPGS

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FPGS
Gene description	Folylpolyglutamate synthase
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, highly abundant in smooth muscles.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA050488
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FPGS
Synonyms
Description	Folylpolyglutamate synthase (HGNC Symbol)
Entrez gene summary	This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	127794597 - 127814327
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136877 (version 83.38)
Entrez gene	2356
UniProt	Q05932 (UniProt - Evidence at protein level)
neXtProt	NX_Q05932
Antibodypedia	FPGS antibodies

PROTEIN BROWSER

FPGS-001	FPGS-011	FPGS-012	FPGS-017	FPGS-020	FPGS-201	FPGS-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FPGS-001 ENSP00000406328 ENST00000423577	Q5JU21 [Direct mapping] Folylpolyglutamate synthase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004326 [tetrahydrofolylpolyglutamate synthase activity] GO:0005524 [ATP binding] GO:0009058 [biosynthetic process] GO:0009396 [folic acid-containing compound biosynthetic process] GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process] Show all	194 aa 21.6 kDa	No	0
FPGS-011 ENSP00000362344 ENST00000373247	Q05932 [Direct mapping] Folylpolyglutamate synthase, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0004326 [tetrahydrofolylpolyglutamate synthase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006536 [glutamate metabolic process] GO:0006730 [one-carbon metabolic process] GO:0006760 [folic acid-containing compound metabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0007420 [brain development] GO:0008283 [cell proliferation] GO:0009058 [biosynthetic process] GO:0009396 [folic acid-containing compound biosynthetic process] GO:0016874 [ligase activity] GO:0031100 [organ regeneration] GO:0044281 [small molecule metabolic process] GO:0046655 [folic acid metabolic process] GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process] Show all	587 aa 64.6 kDa	Yes	0
FPGS-012 ENSP00000362322 ENST00000373225	Q05932 [Direct mapping] Folylpolyglutamate synthase, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004326 [tetrahydrofolylpolyglutamate synthase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006536 [glutamate metabolic process] GO:0006730 [one-carbon metabolic process] GO:0006760 [folic acid-containing compound metabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0008283 [cell proliferation] GO:0009058 [biosynthetic process] GO:0009396 [folic acid-containing compound biosynthetic process] GO:0016874 [ligase activity] GO:0044281 [small molecule metabolic process] GO:0046655 [folic acid metabolic process] GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process] Show all	537 aa 59.2 kDa	No	0
FPGS-017 ENSP00000362325 ENST00000373228	Q5JU23 [Direct mapping] Folylpolyglutamate synthase, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004326 [tetrahydrofolylpolyglutamate synthase activity] GO:0005524 [ATP binding] GO:0009058 [biosynthetic process] GO:0009396 [folic acid-containing compound biosynthetic process] GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process] Show all	375 aa 40.9 kDa	Yes	0
FPGS-020 ENSP00000400007 ENST00000431857	Q5JU20 [Direct mapping] Folylpolyglutamate synthase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004326 [tetrahydrofolylpolyglutamate synthase activity] GO:0005524 [ATP binding] GO:0009058 [biosynthetic process] GO:0009396 [folic acid-containing compound biosynthetic process] GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process] Show all	265 aa 29.2 kDa	No	0
FPGS-201 ENSP00000377309 ENST00000393706	Q05932 [Direct mapping] Folylpolyglutamate synthase, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004326 [tetrahydrofolylpolyglutamate synthase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006536 [glutamate metabolic process] GO:0006730 [one-carbon metabolic process] GO:0006760 [folic acid-containing compound metabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0008283 [cell proliferation] GO:0009058 [biosynthetic process] GO:0009396 [folic acid-containing compound biosynthetic process] GO:0016874 [ligase activity] GO:0044281 [small molecule metabolic process] GO:0046655 [folic acid metabolic process] GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process] Show all	561 aa 61.6 kDa	Yes	0
FPGS-202 ENSP00000486766 ENST00000630236	Q5JU23 [Direct mapping] Folylpolyglutamate synthase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004326 [tetrahydrofolylpolyglutamate synthase activity] GO:0005524 [ATP binding] GO:0009058 [biosynthetic process] GO:0009396 [folic acid-containing compound biosynthetic process] GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process] Show all	375 aa 40.9 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.