Expression of DPM2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA064623

GENE INFORMATION
Gene name	DPM2 (HGNC Symbol)
Synonyms	MGC111193, MGC21559
Description	Dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit (HGNC Symbol)
Entrez gene summary	Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	127935099 - 127938484
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136908 (version 83.38)
Entrez gene	8818
UniProt	O94777 (UniProt - Evidence at protein level)
neXtProt	NX_O94777
Antibodypedia	DPM2 antibodies

PROTEIN BROWSER

DPM2-001	DPM2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPM2-001 ENSP00000322181 ENST00000314392	O94777 [Direct mapping] Dolichol phosphate-mannose biosynthesis regulatory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0004582 [dolichyl-phosphate beta-D-mannosyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0009059 [macromolecule biosynthetic process] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019348 [dolichol metabolic process] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030234 [enzyme regulator activity] GO:0031647 [regulation of protein stability] GO:0033185 [dolichol-phosphate-mannose synthase complex] GO:0035269 [protein O-linked mannosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0050790 [regulation of catalytic activity] Show all	84 aa 9.3 kDa	No	2
DPM2-003 ENSP00000362202 ENST00000373110	Q5T9C7 [Direct mapping] Dolichol phosphate-mannose biosynthesis regulatory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0009059 [macromolecule biosynthetic process] GO:0019348 [dolichol metabolic process] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030234 [enzyme regulator activity] GO:0050790 [regulation of catalytic activity] Show all	130 aa 14.1 kDa	No	2