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RNA tissue category: Group enriched (cerebral cortex, cerebellum, hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, brain, hippocampus)
GENE INFORMATION
Gene name
GABBR2 (HGNC Symbol)
Synonyms
GABABR2, GPR51, GPRC3B, HG20
Description
Gamma-aminobutyric acid (GABA) B receptor, 2 (HGNC Symbol)
Entrez gene summary
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
