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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]
Enzymes ENZYME proteins Hydrolases Peptidases Threonine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006595 [polyamine metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0010499 [proteasomal ubiquitin-independent protein catabolic process] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034641 [cellular nitrogen compound metabolic process] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043488 [regulation of mRNA stability] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050852 [T cell receptor signaling pathway] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular exosome] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1903955 [positive regulation of protein targeting to mitochondrion]
