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Most malignancies showed moderate to strong nuclear positivity. Hepatocellular, pancreatic and renal cancers were generally weak or negative.
GENE INFORMATION
Gene name
XPA (HGNC Symbol)
Synonyms
XP1, XPAC
Description
Xeroderma pigmentosum, complementation group A (HGNC Symbol)
Entrez gene summary
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
P23025 [Direct mapping] DNA repair protein complementing XP-A cells
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
