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IL33

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GENERAL INFORMATION

Gene name

 IL33

Gene description

 Interleukin 33

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Cell line enriched (U-2197)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA052386
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (U-2197)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA052386 BJ Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 IL33 (HGNC Symbol)

Synonyms

 C9orf26, DKFZp586H0523, DVS27, IL1F11, NF-HEV

Description

 Interleukin 33 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Chromosome

 9

Cytoband

 p24.1

Chromosome location (bp)

 6215786 - 6257983

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137033 (version 83.38)

Entrez gene

 90865

UniProt

 O95760 (UniProt - Evidence at protein level)

neXtProt

 NX_O95760

Antibodypedia

 IL33 antibodies

PROTEIN BROWSER
IL33-001
IL33-201
IL33-202
IL33-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL33-001
ENSP00000370842
ENST00000381434
O95760 [Direct mapping]
Interleukin-33 Interleukin-33 (95-270) Interleukin-33 (99-270) Interleukin-33 (109-270)
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002686 [negative regulation of leukocyte migration]
GO:0002826 [negative regulation of T-helper 1 type immune response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0006351 [transcription, DNA-templated]
GO:0010628 [positive regulation of gene expression]
GO:0030133 [transport vesicle]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032736 [positive regulation of interleukin-13 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0043032 [positive regulation of macrophage activation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050729 [positive regulation of inflammatory response]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0051025 [negative regulation of immunoglobulin secretion]
GO:0051607 [defense response to virus]
GO:0090197 [positive regulation of chemokine secretion]
GO:0097191 [extrinsic apoptotic signaling pathway]
Show all
 270 aa
30.8 kDa 		No 0
IL33-201
ENSP00000394039
ENST00000417746
O95760 [Direct mapping]
Interleukin-33 Interleukin-33 (95-270) Interleukin-33 (99-270) Interleukin-33 (109-270)
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0006351 [transcription, DNA-templated]
GO:0030133 [transport vesicle]
GO:0043032 [positive regulation of macrophage activation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050729 [positive regulation of inflammatory response]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 144 aa
16.2 kDa 		No 0
IL33-202
ENSP00000414238
ENST00000456383
O95760 [Direct mapping]
Interleukin-33 Interleukin-33 (95-270) Interleukin-33 (99-270) Interleukin-33 (109-270)
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0006351 [transcription, DNA-templated]
GO:0030133 [transport vesicle]
GO:0043032 [positive regulation of macrophage activation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050729 [positive regulation of inflammatory response]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 228 aa
25.9 kDa 		No 0
IL33-203
ENSP00000478858
ENST00000611532
O95760 [Direct mapping]
Interleukin-33 Interleukin-33 (95-270) Interleukin-33 (99-270) Interleukin-33 (109-270)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0006351 [transcription, DNA-templated]
GO:0030133 [transport vesicle]
GO:0043032 [positive regulation of macrophage activation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050729 [positive regulation of inflammatory response]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 228 aa
26.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.