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TLN1

CANCER ATLAS

Gene description

 Talin 1

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004748
CAB002006

GENE INFORMATION

Gene name

 TLN1 (HGNC Symbol)

Synonyms

 ILWEQ, TLN

Description

 Talin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 35696948 - 35732395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137076 (version 83.38)

Entrez gene

 7094

UniProt

 Q9Y490 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y490

Antibodypedia

 TLN1 antibodies

PROTEIN BROWSER
TLN1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TLN1-001
ENSP00000316029
ENST00000314888
Q9Y490 [Direct mapping]
Talin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002576 [platelet degranulation]
GO:0003779 [actin binding]
GO:0005158 [insulin receptor binding]
GO:0005178 [integrin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007043 [cell-cell junction assembly]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016032 [viral process]
GO:0017166 [vinculin binding]
GO:0030168 [platelet activation]
GO:0030274 [LIM domain binding]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032403 [protein complex binding]
GO:0032587 [ruffle membrane]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
Show all
 2541 aa
269.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.