Expression of SIT1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Signaling threshold regulating transmembrane adaptor 1

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Lymphoma

STAINING SUMMARY

HPA018506

GENE INFORMATION
Gene name	SIT1 (HGNC Symbol)
Synonyms	SIT
Description	Signaling threshold regulating transmembrane adaptor 1 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	35649295 - 35650950
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137078 (version 83.38)
Entrez gene	27240
UniProt	Q9Y3P8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3P8
Antibodypedia	SIT1 antibodies

PROTEIN BROWSER

SIT1-001	SIT1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIT1-001 ENSP00000259608 ENST00000259608	Q9Y3P8 [Direct mapping] Signaling threshold-regulating transmembrane adapter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0019900 [kinase binding] GO:0042169 [SH2 domain binding] GO:0050863 [regulation of T cell activation] GO:0070062 [extracellular exosome] Show all	196 aa 21.1 kDa	Yes	1
SIT1-201 ENSP00000481347 ENST00000618781	A0A087WXW3 [Direct mapping] Signaling threshold-regulating transmembrane adapter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	224 aa 24.2 kDa	Yes	1