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IFNA21

GENERAL INFORMATION

Gene name

 IFNA21

Gene description

 Interferon, alpha 21

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 1 antibody.
HPA047557
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 IFNA21 (HGNC Symbol)

Synonyms

 IFN-alphaI

Description

 Interferon, alpha 21 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]

Chromosome

 9

Cytoband

 p21.3

Chromosome location (bp)

 21165637 - 21166660

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137080 (version 83.38)

Entrez gene

 3452

UniProt

 P01568 (UniProt - Evidence at protein level)

neXtProt

 NX_P01568

Antibodypedia

 IFNA21 antibodies

PROTEIN BROWSER
IFNA21-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFNA21-001
ENSP00000369574
ENST00000380225
P01568 [Direct mapping]
Interferon alpha-21
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0002250 [adaptive immune response]
GO:0002286 [T cell activation involved in immune response]
GO:0002323 [natural killer cell activation involved in immune response]
GO:0005125 [cytokine activity]
GO:0005126 [cytokine receptor binding]
GO:0005132 [type I interferon receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006952 [defense response]
GO:0006959 [humoral immune response]
GO:0007596 [blood coagulation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030183 [B cell differentiation]
GO:0033141 [positive regulation of peptidyl-serine phosphorylation of STAT protein]
GO:0042100 [B cell proliferation]
GO:0043330 [response to exogenous dsRNA]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
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 189 aa
21.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.