Expression of GRHPR in cancer - Summary

CANCER ATLAS

Gene description

Glyoxylate reductase/hydroxypyruvate reductase

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA022971

GENE INFORMATION
Gene name	GRHPR (HGNC Symbol)
Synonyms	GLXR, PH2
Description	Glyoxylate reductase/hydroxypyruvate reductase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p13.2
Chromosome location (bp)	37422666 - 37436990
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137106 (version 83.38)
Entrez gene	9380
UniProt	Q9UBQ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBQ7
Antibodypedia	GRHPR antibodies

PROTEIN BROWSER

GRHPR-002	GRHPR-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRHPR-002 ENSP00000313432 ENST00000318158	Q9UBQ7 [Direct mapping] Glyoxylate reductase/hydroxypyruvate reductase Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005782 [peroxisomal matrix] GO:0005829 [cytosol] GO:0007588 [excretion] GO:0008152 [metabolic process] GO:0008465 [glycerate dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0016618 [hydroxypyruvate reductase activity] GO:0030267 [glyoxylate reductase (NADP) activity] GO:0031406 [carboxylic acid binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042803 [protein homodimerization activity] GO:0043648 [dicarboxylic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046487 [glyoxylate metabolic process] GO:0050661 [NADP binding] GO:0051259 [protein oligomerization] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0070402 [NADPH binding] Show all	328 aa 35.7 kDa	No	0
GRHPR-011 ENSP00000475569 ENST00000607784	U3KQ56 [Direct mapping] Glyoxylate reductase/hydroxypyruvate reductase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	358 aa 38.7 kDa	No	0