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ALDH1B1

GENERAL INFORMATION

Gene name

 ALDH1B1

Gene description

 Aldehyde dehydrogenase 1 family, member B1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA021037
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ALDH1B1 (HGNC Symbol)

Synonyms

 ALDH5, ALDHX

Description

 Aldehyde dehydrogenase 1 family, member B1 (HGNC Symbol)

Entrez gene summary

 This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 p13.1

Chromosome location (bp)

 38392664 - 38398661

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137124 (version 83.38)

Entrez gene

 219

UniProt

 P30837 (UniProt - Evidence at protein level)

neXtProt

 NX_P30837

Antibodypedia

 ALDH1B1 antibodies

PROTEIN BROWSER
ALDH1B1-001
ALDH1B1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH1B1-001
ENSP00000366927
ENST00000377698
P30837 [Direct mapping]
Aldehyde dehydrogenase X, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005975 [carbohydrate metabolic process]
GO:0006068 [ethanol catabolic process]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 517 aa
57.2 kDa 		No 0
ALDH1B1-002
ENSP00000489053
ENST00000635162
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 130 aa
14.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.