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HINT2

GENERAL INFORMATION

Gene name

 HINT2

Gene description

 Histidine triad nucleotide binding protein 2

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues, including kidney, pancreas and liver.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA020961 , HPA059109
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HINT2

Synonyms

Description

 Histidine triad nucleotide binding protein 2 (HGNC Symbol)

Entrez gene summary

 Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 35812960 - 35815354

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137133 (version 83.38)

Entrez gene

 84681

UniProt

 Q9BX68 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BX68

Antibodypedia

 HINT2 antibodies

PROTEIN BROWSER
HINT2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HINT2-002
ENSP00000259667
ENST00000259667
Q9BX68 [Direct mapping]
Histidine triad nucleotide-binding protein 2, mitochondrial
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003824 [catalytic activity]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0006694 [steroid biosynthetic process]
GO:0006915 [apoptotic process]
GO:0016787 [hydrolase activity]
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 163 aa
17.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.