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TFAP2A

GENERAL INFORMATION

Gene name

 TFAP2A

Gene description

 Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin, placenta, breast)
GTEx:Tissue enhanced (skin)
FANTOM5:Tissue enhanced (placenta, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Selective nuclear expression in trophoblastic cells and squamous epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA028850 , HPA056871 , CAB000326
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin, placenta, breast)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta, retina)

GENE INFORMATION

Gene name

 TFAP2A (HGNC Symbol)

Synonyms

 AP-2, AP2TF, TFAP2

Description

 Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

Chromosome

 6

Cytoband

 p24.3

Chromosome location (bp)

 10393186 - 10419659

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137203 (version 83.38)

Entrez gene

 7020

UniProt

 P05549 (UniProt - Evidence at protein level)

neXtProt

 NX_P05549

Antibodypedia

 TFAP2A antibodies

PROTEIN BROWSER
TFAP2A-001
TFAP2A-003
TFAP2A-005
TFAP2A-007
TFAP2A-009
TFAP2A-010
TFAP2A-016
TFAP2A-017
TFAP2A-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TFAP2A-001
ENSP00000368933
ENST00000379613
Q96SH1 [Direct mapping]
Transcription factor AP-2 alpha (Activating enhancer binding protein 2 alpha), isoform CRA_c; Transcription factor AP-2-alpha
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 439 aa
48.3 kDa 		No 0
TFAP2A-003
ENSP00000316516
ENST00000319516
P05549 [Direct mapping]
Transcription factor AP-2-alpha
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001822 [kidney development]
GO:0003404 [optic vesicle morphogenesis]
GO:0003409 [optic cup structural organization]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007605 [sensory perception of sound]
GO:0008285 [negative regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010842 [retina layer formation]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0021559 [trigeminal nerve development]
GO:0021623 [oculomotor nerve formation]
GO:0030501 [positive regulation of bone mineralization]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0042472 [inner ear morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0060021 [palate development]
GO:0060349 [bone morphogenesis]
GO:0061029 [eyelid development in camera-type eye]
GO:0070172 [positive regulation of tooth mineralization]
GO:0071281 [cellular response to iron ion]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
 433 aa
47.4 kDa 		No 0
TFAP2A-005
ENSP00000368928
ENST00000379608
P05549 [Direct mapping]
Transcription factor AP-2-alpha
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001822 [kidney development]
GO:0003404 [optic vesicle morphogenesis]
GO:0003409 [optic cup structural organization]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007605 [sensory perception of sound]
GO:0008285 [negative regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010842 [retina layer formation]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0021559 [trigeminal nerve development]
GO:0021623 [oculomotor nerve formation]
GO:0030501 [positive regulation of bone mineralization]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0042472 [inner ear morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0060021 [palate development]
GO:0060349 [bone morphogenesis]
GO:0061029 [eyelid development in camera-type eye]
GO:0070172 [positive regulation of tooth mineralization]
GO:0071281 [cellular response to iron ion]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
 431 aa
47.2 kDa 		No 0
TFAP2A-007
ENSP00000418541
ENST00000482890
P05549 [Direct mapping]
Transcription factor AP-2-alpha
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001822 [kidney development]
GO:0003404 [optic vesicle morphogenesis]
GO:0003409 [optic cup structural organization]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007605 [sensory perception of sound]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009414 [response to water deprivation]
GO:0010033 [response to organic substance]
GO:0010628 [positive regulation of gene expression]
GO:0010842 [retina layer formation]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0014044 [Schwann cell development]
GO:0021559 [trigeminal nerve development]
GO:0021623 [oculomotor nerve formation]
GO:0030501 [positive regulation of bone mineralization]
GO:0032496 [response to lipopolysaccharide]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0042472 [inner ear morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0060021 [palate development]
GO:0060349 [bone morphogenesis]
GO:0061029 [eyelid development in camera-type eye]
GO:0070172 [positive regulation of tooth mineralization]
GO:0071281 [cellular response to iron ion]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
 437 aa
48.1 kDa 		No 0
TFAP2A-009
ENSP00000419961
ENST00000498450
C9JXZ2 [Direct mapping]
Transcription factor AP-2-alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 136 aa
14.7 kDa 		No 0
TFAP2A-010
ENSP00000417495
ENST00000466073
C1K3N0 [Direct mapping]
Transcription factor AP-2 alpha; Transcription factor AP-2-alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 328 aa
35.9 kDa 		No 0
TFAP2A-016
ENSP00000418391
ENST00000465858
C9J6N8 [Direct mapping]
Transcription factor AP-2-alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 173 aa
19 kDa 		No 0
TFAP2A-017
ENSP00000417735
ENST00000461628
H7C4N4 [Direct mapping]
Transcription factor AP-2-alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 81 aa
8.7 kDa 		No 0
TFAP2A-018
ENSP00000419696
ENST00000475264
H7C5E5 [Direct mapping]
Transcription factor AP-2-alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 218 aa
23.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.