Fields »
ABOUT
HELP
BLOG
TINAG

GENERAL INFORMATION

Gene name

 TINAG

Gene description

 Tubulointerstitial nephritis antigen

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (kidney)
GTEx:Group enriched (kidney, small intestine, colon)
FANTOM5:Tissue enhanced (kidney, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in basal membrane of proximal tubules in kidney. Cytoplasmic expression in small intestines, colon and rectum.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA035427
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, small intestine, colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney, small intestine)

GENE INFORMATION

Gene name

 TINAG

Synonyms

Description

 Tubulointerstitial nephritis antigen (HGNC Symbol)

Entrez gene summary

 This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]

Chromosome

 6

Cytoband

 p12.1

Chromosome location (bp)

 54307859 - 54390152

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137251 (version 83.38)

Entrez gene

 27283

UniProt

 Q9UJW2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UJW2

Antibodypedia

 TINAG antibodies

PROTEIN BROWSER
TINAG-001
TINAG-003
TINAG-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TINAG-001
ENSP00000259782
ENST00000259782
Q9UJW2 [Direct mapping]
Tubulointerstitial nephritis antigen
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005044 [scavenger receptor activity]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0006898 [receptor-mediated endocytosis]
GO:0006955 [immune response]
GO:0007155 [cell adhesion]
GO:0008234 [cysteine-type peptidase activity]
GO:0030247 [polysaccharide binding]
Show all
 476 aa
54.6 kDa 		No 0
TINAG-003
ENSP00000359901
ENST00000370864
Q5T466 [Direct mapping]
Tubulointerstitial nephritis antigen
Show all
Predicted intracellular proteins
Show all
GO:0005044 [scavenger receptor activity]
GO:0005615 [extracellular space]
GO:0006898 [receptor-mediated endocytosis]
GO:0006955 [immune response]
GO:0008234 [cysteine-type peptidase activity]
GO:0030247 [polysaccharide binding]
Show all
 203 aa
23.7 kDa 		No 0
TINAG-005
ENSP00000359906
ENST00000370869
Q5T471 [Direct mapping]
Tubulointerstitial nephritis antigen
Show all
Predicted intracellular proteins
Show all
GO:0005044 [scavenger receptor activity]
GO:0005615 [extracellular space]
GO:0006898 [receptor-mediated endocytosis]
GO:0006955 [immune response]
GO:0008234 [cysteine-type peptidase activity]
GO:0030247 [polysaccharide binding]
Show all
 205 aa
24.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.