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HCRTR2

GENERAL INFORMATION

Gene name

 HCRTR2

Gene description

 Hypocretin (orexin) receptor 2

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Tissue enhanced (hypothalamus)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in CNS.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining pattern while RNA data does not.

Reliability score

 Supported based on 1 antibody.
HPA054516
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 HCRTR2 (HGNC Symbol)

Synonyms

 OX2R

Description

 Hypocretin (orexin) receptor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

Chromosome

 6

Cytoband

 p12.1

Chromosome location (bp)

 55106460 - 55282620

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137252 (version 83.38)

Entrez gene

 3062

UniProt

 O43614 (UniProt - Evidence at protein level)

neXtProt

 NX_O43614

Antibodypedia

 HCRTR2 antibodies

PROTEIN BROWSER
HCRTR2-001
HCRTR2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HCRTR2-001
ENSP00000359899
ENST00000370862
O43614 [Direct mapping]
Orexin receptor type 2
S4X0W3 [Target identity:100%; Query identity:100%]
Orexin type-2 receptor isoform 1
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007631 [feeding behavior]
GO:0008188 [neuropeptide receptor activity]
GO:0016021 [integral component of membrane]
GO:0016499 [orexin receptor activity]
GO:0022410 [circadian sleep/wake cycle process]
GO:0032870 [cellular response to hormone stimulus]
GO:0042277 [peptide binding]
GO:0045187 [regulation of circadian sleep/wake cycle, sleep]
GO:1901652 [response to peptide]
Show all
 444 aa
50.7 kDa 		No 7
HCRTR2-201
ENSP00000477548
ENST00000615358
O43614 [Direct mapping]
Orexin receptor type 2
S4X0W3 [Target identity:100%; Query identity:100%]
Orexin type-2 receptor isoform 1
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007631 [feeding behavior]
GO:0008188 [neuropeptide receptor activity]
GO:0016021 [integral component of membrane]
GO:0016499 [orexin receptor activity]
GO:0017046 [peptide hormone binding]
GO:0022410 [circadian sleep/wake cycle process]
GO:0032870 [cellular response to hormone stimulus]
GO:0042277 [peptide binding]
GO:0045187 [regulation of circadian sleep/wake cycle, sleep]
GO:1901652 [response to peptide]
Show all
 444 aa
50.7 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.