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Gene name

Class

Subclass

Chromosome

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In atlas

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Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

Tissue

Cell type

Expression

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Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

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Antibodies

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RIPK1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

RIPK1

Gene description

Receptor (TNFRSF)-interacting serine-threonine kinase 1

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA015257 , CAB010302
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

RIPK1 (HGNC Symbol)

Synonyms

RIP

Description

Receptor (TNFRSF)-interacting serine-threonine kinase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

6

Cytoband

p25.2

Chromosome location (bp)

3063991 - 3115187

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137275 (version 83.38)

Entrez gene

8737

UniProt

Q13546 (UniProt - Evidence at protein level)

neXtProt

NX_Q13546

Antibodypedia

RIPK1 antibodies

PROTEIN BROWSER

RIPK1-005
RIPK1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RIPK1-005
ENSP00000259808
ENST00000259808
Q13546 [Direct mapping]
Receptor-interacting serine/threonine-protein kinase 1
A0A024QZU0 [Target identity:100%; Query identity:100%]
Receptor (TNFRSF)-interacting serine-threonine kinase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007257 [activation of JUN kinase activity]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0010942 [positive regulation of cell death]
GO:0012501 [programmed cell death]
GO:0031264 [death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032403 [protein complex binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0036289 [peptidyl-serine autophosphorylation]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043068 [positive regulation of programmed cell death]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043234 [protein complex]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0044257 [cellular protein catabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0060545 [positive regulation of necroptotic process]
GO:0070231 [T cell apoptotic process]
GO:0070266 [necroptotic process]
GO:0070513 [death domain binding]
GO:0070926 [regulation of ATP:ADP antiporter activity]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071550 [death-inducing signaling complex assembly]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:0097343 [ripoptosome assembly]
GO:0097527 [necroptotic signaling pathway]
GO:1901026 [ripoptosome assembly involved in necroptotic process]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1990000 [amyloid fibril formation]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
671 aa
75.9 kDa
No 0
RIPK1-201
ENSP00000369773
ENST00000380409
Q13546 [Direct mapping]
Receptor-interacting serine/threonine-protein kinase 1
A0A024QZU0 [Target identity:100%; Query identity:100%]
Receptor (TNFRSF)-interacting serine-threonine kinase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007257 [activation of JUN kinase activity]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0031264 [death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032403 [protein complex binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0036289 [peptidyl-serine autophosphorylation]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043068 [positive regulation of programmed cell death]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043235 [receptor complex]
GO:0044257 [cellular protein catabolic process]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0060545 [positive regulation of necroptotic process]
GO:0070231 [T cell apoptotic process]
GO:0070266 [necroptotic process]
GO:0070513 [death domain binding]
GO:0070926 [regulation of ATP:ADP antiporter activity]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071550 [death-inducing signaling complex assembly]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:0097343 [ripoptosome assembly]
GO:0097527 [necroptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1990000 [amyloid fibril formation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
671 aa
75.9 kDa
No 0

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  • INTRODUCTION
  • ORGANIZATION
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  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.