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HMGA1

CANCER ATLAS

Gene description

 High mobility group AT-hook 1

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB032200

GENE INFORMATION

Gene name

 HMGA1 (HGNC Symbol)

Synonyms

 HMGIY

Description

 High mobility group AT-hook 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 34236873 - 34246231

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000137309 (version 83.38)

Entrez gene

 3159

UniProt

 P17096 (UniProt - Evidence at protein level)

neXtProt

 NX_P17096

Antibodypedia

 HMGA1 antibodies

PROTEIN BROWSER
HMGA1-001
HMGA1-002
HMGA1-004
HMGA1-201
HMGA1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMGA1-001
ENSP00000288245
ENST00000347617
P17096 [Direct mapping]
High mobility group protein HMG-I/HMG-Y
Q5T6U8 [Target identity:100%; Query identity:100%]
High mobility group AT-hook 1
Show all
Predicted intracellular proteins
Transcription factors
   beta-Sheet binding to DNA
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003680 [AT DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006284 [base-excision repair]
GO:0006337 [nucleosome disassembly]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0031936 [negative regulation of chromatin silencing]
GO:0035985 [senescence-associated heterochromatin focus]
GO:0035986 [senescence-associated heterochromatin focus assembly]
GO:0042974 [retinoic acid receptor binding]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0075713 [establishment of integrated proviral latency]
GO:0090402 [oncogene-induced cell senescence]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000774 [positive regulation of cellular senescence]
Show all
 96 aa
10.7 kDa 		No 0
HMGA1-002
ENSP00000385693
ENST00000401473
P17096 [Direct mapping]
High mobility group protein HMG-I/HMG-Y
Q5T6U8 [Target identity:100%; Query identity:100%]
High mobility group AT-hook 1
Show all
Predicted intracellular proteins
Transcription factors
   beta-Sheet binding to DNA
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003680 [AT DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006284 [base-excision repair]
GO:0006337 [nucleosome disassembly]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0031936 [negative regulation of chromatin silencing]
GO:0035985 [senescence-associated heterochromatin focus]
GO:0035986 [senescence-associated heterochromatin focus assembly]
GO:0042974 [retinoic acid receptor binding]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0075713 [establishment of integrated proviral latency]
GO:0090402 [oncogene-induced cell senescence]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000774 [positive regulation of cellular senescence]
Show all
 96 aa
10.7 kDa 		No 0
HMGA1-004
ENSP00000308227
ENST00000311487
P17096 [Direct mapping]
High mobility group protein HMG-I/HMG-Y
Show all
Predicted intracellular proteins
Transcription factors
   beta-Sheet binding to DNA
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003680 [AT DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006284 [base-excision repair]
GO:0006337 [nucleosome disassembly]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0031936 [negative regulation of chromatin silencing]
GO:0035985 [senescence-associated heterochromatin focus]
GO:0035986 [senescence-associated heterochromatin focus assembly]
GO:0042974 [retinoic acid receptor binding]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0075713 [establishment of integrated proviral latency]
GO:0090402 [oncogene-induced cell senescence]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000774 [positive regulation of cellular senescence]
Show all
 107 aa
11.7 kDa 		No 0
HMGA1-201
ENSP00000363230
ENST00000374116
P17096 [Direct mapping]
High mobility group protein HMG-I/HMG-Y
Q5T6U8 [Target identity:100%; Query identity:100%]
High mobility group AT-hook 1
Show all
Predicted intracellular proteins
Transcription factors
   beta-Sheet binding to DNA
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003680 [AT DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006284 [base-excision repair]
GO:0006337 [nucleosome disassembly]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0031936 [negative regulation of chromatin silencing]
GO:0035985 [senescence-associated heterochromatin focus]
GO:0035986 [senescence-associated heterochromatin focus assembly]
GO:0042974 [retinoic acid receptor binding]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0075713 [establishment of integrated proviral latency]
GO:0090402 [oncogene-induced cell senescence]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000774 [positive regulation of cellular senescence]
Show all
 96 aa
10.7 kDa 		No 0
HMGA1-202
ENSP00000399888
ENST00000447654
P17096 [Direct mapping]
High mobility group protein HMG-I/HMG-Y
Show all
Predicted intracellular proteins
Transcription factors
   beta-Sheet binding to DNA
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003680 [AT DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006284 [base-excision repair]
GO:0006337 [nucleosome disassembly]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0031936 [negative regulation of chromatin silencing]
GO:0035985 [senescence-associated heterochromatin focus]
GO:0035986 [senescence-associated heterochromatin focus assembly]
GO:0042974 [retinoic acid receptor binding]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0075713 [establishment of integrated proviral latency]
GO:0090402 [oncogene-induced cell senescence]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000774 [positive regulation of cellular senescence]
Show all
 107 aa
11.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.